Safety of long-term treatment of HAM/TSP patients with valproic acid
| العنوان: | Safety of long-term treatment of HAM/TSP patients with valproic acid |
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| المؤلفون: | Gildas Belrose, Agnès Lézin, Nicolas Gillet, Luc Willems, Mathieu Boxus, Raymond Césaire, Sabrina Rodriguez, Charles R. M. Bangham, Becca Asquith, Olivier Verlaeten, Stéphane Olindo, Didier Smadja, Aissatou Signate |
| المصدر: | Blood. 118:6306-6309 |
| بيانات النشر: | American Society of Hematology, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, CD4-Positive T-Lymphocytes, Male, medicine.medical_specialty, Time Factors, medicine.drug_class, Immunology, CD8-Positive T-Lymphocytes, Biology, Pharmacology, Lymphocyte Activation, Severity of Illness Index, Biochemistry, Myelopathy, Proviruses, immune system diseases, Internal medicine, Tropical spastic paraparesis, medicine, Humans, Enzyme Inhibitors, Adverse effect, Aged, Human T-lymphotropic virus 1, Immunity, Cellular, Valproic Acid, Hematology, Histone deacetylase inhibitor, virus diseases, Cell Biology, Middle Aged, Viral Load, medicine.disease, Paraparesis, Tropical Spastic, Discontinuation, Cytophagocytosis, Female, lipids (amino acids, peptides, and proteins), T-Lymphocytes, Cytotoxic, medicine.drug, Deacetylase activity |
| الوصف: | HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease of the central nervous system induced by human T-lymphotropic virus type 1. As a potential therapeutic approach, we previously suggested reducing the proviral load by modulating lysine deacetylase activity using valproic acid (VPA) and exposing virus-positive cells to the host immune response. We conducted a single-center, 2-year, open-label trial, with 19 HAM/TSP volunteers treated with oral VPA. Proviral load, CD38/HLA-DR expression, and CD8+ lysis efficiency were not significantly affected by VPA. Mean scores of HAM/TSP disability did not differ between baseline and final visit. Walking Time Test increased significantly (> 20%) in 3 patients and was in keeping with minor VPA side effects (drowsiness and tremor). Walking Time Test improved rapidly after VPA discontinuation. We conclude that long-term treatment with VPA is safe in HAM/TSP. |
| تدمد: | 1528-0020 0006-4971 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3704092f85654f43cc86dfcfe7c2825d https://doi.org/10.1182/blood-2011-04-349910 |
| رقم الأكسشن: | edsair.doi.dedup.....3704092f85654f43cc86dfcfe7c2825d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15280020 00064971 |
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