Molecular Mechanisms Affecting HTLV Type 1-Dependent Fusion at the Cell Membrane: Implications for Inhibiting Viral Transmission
| العنوان: | Molecular Mechanisms Affecting HTLV Type 1-Dependent Fusion at the Cell Membrane: Implications for Inhibiting Viral Transmission |
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| المؤلفون: | Susan Daenke, Sarah Booth |
| المصدر: | AIDS Research and Human Retroviruses. 16:1731-1736 |
| بيانات النشر: | Mary Ann Liebert Inc, 2000. |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Gene Expression Regulation, Viral, Integrins, Fusion Regulatory Protein-1, viruses, Molecular Sequence Data, Retroviridae Proteins, Oncogenic, Immunology, Biology, Membrane Fusion, Virus, Cell Line, Cell membrane, Cytopathogenic Effect, Viral, Antigen, Antigens, CD, Virology, medicine, Humans, Amino Acid Sequence, Human T-lymphotropic virus 1, Cell fusion, env Gene Products, Human Immunodeficiency Virus, Gene Products, env, Lipid bilayer fusion, HTLV-I Infections, Chronic infection, Infectious Diseases, medicine.anatomical_structure, Cell culture, Receptors, Virus, Carrier Proteins |
| الوصف: | Infection with human T cell leukemia virus type 1 is detected by screening programs and contact follow-up procedures. Where chronic infection results in overt pathology, this is treated largely symptomatically and control of transmission relies on physical and educational constraints. The poor infectious transmission rate of HTLV-1 has long been described but to date has not been exploited in preventative measures to combat the spread of the virus. We undertook to investigate some of the molecular steps involved in HTLV-1 cell-cell fusion, the main mechanism of transmission. We showed that poor transmission may relate in part to an inefficiency in adopting and maintaining a fusion competent conformation of the HTLV-1 envelope TM protein. In cell-cell fusion, this deficiency can be complemented by accessory molecules on both infected and target cells that stabilize the envelope/receptor interaction. In virion-cell fusion, this is less likely, leading to an inefficient interaction and poor infectious transmission by cell-free virus. A discussion of the accessory molecules involved in HTLV-1 fusion is presented. This weak envelope-dependent interaction with target cells in the host can be potently disrupted by peptides that destabilize the TM protein structure and significantly inhibit HTLV-1 fusion. These observations may be useful in the design of therapeutic agents to prevent HTLV-1 transmission. |
| تدمد: | 1931-8405 0889-2229 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3714c5ba0a28df9e331af7653c3aabcf https://doi.org/10.1089/08892220050193227 |
| رقم الأكسشن: | edsair.doi.dedup.....3714c5ba0a28df9e331af7653c3aabcf |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19318405 08892229 |
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