Role of Th2 cytokines on the onset of asthma induced bymeta‐xylene in mice
| العنوان: | Role of Th2 cytokines on the onset of asthma induced bymeta‐xylene in mice |
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| المؤلفون: | Seong-Gyeol Hong, Yun-Ho Hwang, Ho-Yeol Jang, Hangun Kim, Man-Jeong Paik, Seul-Ki Mun, Sung-Tae Yee, Su-Jin Kim |
| المصدر: | Environmental Toxicology. 34:1121-1128 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Health, Toxicology and Mutagenesis, Th2 cytokines, Xylenes, 010501 environmental sciences, Management, Monitoring, Policy and Law, Toxicology, Immunoglobulin E, 01 natural sciences, Mice, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Airway resistance, medicine, Animals, Humans, Lung, 0105 earth and related environmental sciences, Asthma, Mice, Inbred BALB C, Interleukin-13, biology, business.industry, Interleukin, General Medicine, Th1 Cells, medicine.disease, respiratory tract diseases, Mice, Inbred C57BL, 030220 oncology & carcinogenesis, Immunology, biology.protein, Cytokines, Female, Interleukin-4, Interleukin-5, Airway, business, Bronchoalveolar Lavage Fluid, Infiltration (medical) |
| الوصف: | meta-Xylene (m-xylene) is one of three isomers of xylene, which is widely used as a solvent and detergent in various industries and medical technology. Exposure to volatile organic compounds, such as m-xylene, causes pulmonary inflammation and airway inflammation, thereby contributing to the onset of asthma. Exposure to m-xylene increases acute wheezing and intensity of asthma symptom. However, the mechanism of the onset of asthma by m-xylene has not been studied yet. C57BL/6 mice were sensitized and challenged by m-xylene at 100 or 300 mg/kg. The mice were then sacrificed after the last challenge. Exposure to m-xylene increased the total number of inflammatory cells and the production of interleukin (IL)-4, IL-5, IL-13, and immunoglobulin E related to the Th2 immune response. In contrast, the production of interferon-γ related to the Th1 immune response was decreased. In addition, the airway resistance increased according to the airway hyper-responsiveness measurements. Finally, a histological analysis revealed infiltration of inflammatory cells, mucus production, and lung fibrosis. These results suggest that m-xylene is a potential risk factor for asthma and the onset of asthma is caused by TH2 cytokines. |
| تدمد: | 1522-7278 1520-4081 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39eb2b5277a5ef5953adaabddfd52f12 https://doi.org/10.1002/tox.22814 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....39eb2b5277a5ef5953adaabddfd52f12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15227278 15204081 |
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