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A new synthetic approach to functionalize pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones via a three-component one-pot reaction

التفاصيل البيبلوغرافية
العنوان: A new synthetic approach to functionalize pyrimido[4,5-b]quinoline-2,4(1H,3H)-diones via a three-component one-pot reaction
المؤلفون: Philippe Helissey, Karen Aknin, Stéphanie Desbène-Finck, Sylviane Giorgi-Renault
المصدر: Molecular Diversity. 14:123-130
بيانات النشر: Springer Science and Business Media LLC, 2009.
سنة النشر: 2009
مصطلحات موضوعية: Aniline Compounds, Barbituric acid, Chemical Phenomena, Organic Chemistry, Quinoline, Electron donor, Pyrimidinones, General Medicine, Ring (chemistry), Catalysis, Inorganic Chemistry, chemistry.chemical_compound, chemistry, One pot reaction, Barbiturates, Drug Discovery, Quinolines, Polar effect, Organic chemistry, Physical and Theoretical Chemistry, Benzene, Molecular Biology, Acetic Acid, Information Systems
الوصف: Functionalized pyrimido[4,5-b]quinoline-2,4 (1H,3H)-diones were synthesized by a three-component one-pot reaction involving barbituric acid, aldehydes, and anilines. The use of commercially available anilines allowed the facile syntheses of pyrimido[4,5-b]quinolinediones substituted in all the positions on the benzene ring with electron donor or electron withdrawing groups. This straightforward method circumvents the preparation of unstable substituted 2-aminobenzaldehydes that limits the scope of previously described syntheses. Furthermore, access to the 5-substituted derivatives is now also possible starting from aliphatic or aromatic aldehydes. Our strategy and methodology offer significant and practical improvements over other methodologies.
تدمد: 1573-501X
1381-1991
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3afef373a5fd45059a77ea07a5790145
https://doi.org/10.1007/s11030-009-9154-8
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....3afef373a5fd45059a77ea07a5790145
قاعدة البيانات: OpenAIRE
الوصف
تدمد:1573501X
13811991