Administration of amyloid β-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound
| العنوان: | Administration of amyloid β-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound |
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| المؤلفون: | Jean-Paul Kan, Jean-Jacques Storme, Philippe Soubrie, Gérard Le Fur, Terranova Jean-Paul, Pierre Perreaut |
| المصدر: | Neuroscience Letters. 213:79-82 |
| بيانات النشر: | Elsevier BV, 1996. |
| سنة النشر: | 1996 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Microinjections, Pyridines, Central nervous system, Amnesia, Peptide, Naphthalenes, Non peptide, Neurotrophic factors, Internal medicine, medicine, Animals, Nerve Growth Factors, Rats, Wistar, Cholinergic neuron, Social Behavior, chemistry.chemical_classification, Analysis of Variance, Memory Disorders, Amyloid beta-Peptides, Behavior, Animal, biology, Chemistry, General Neuroscience, Amyloid β peptide, Rats, Serotonin Receptor Agonists, Memory, Short-Term, Neuroprotective Agents, medicine.anatomical_structure, Endocrinology, Cholinergic Fibers, biology.protein, Septal Nuclei, medicine.symptom, Neuroscience, Neurotrophin |
| الوصف: | Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia was observed 4, 7 and 14 days after intraseptal injection of 3 nmol of beta (1-42), beta-(1-40)- and beta (25-35). Lower amounts of beta (1-42) were inactive except 1.5 nmol that disrupted memory 7 days post-treatment. Used as control, the inverted peptide beta (40-1) and the scrambled beta (25-35) were inactive. Using the prolongation procedure, rats infused with 3 nmol of beta (1-40) were still able to recognize the same juvenile. Finally, a daily treatment with the non-peptide neurotrophic compound SR 57746A (10 mg/kg p.o.) over 21 days, prevented the deficits in short-term memory induced by the intraseptal infusion of 3 nmol of either beta (1-40) or beta (25-35). These findings suggest that A beta fragments could impair short-term memory when infused in the rat medial septum, an effect that is prevented by SR 57746A. |
| تدمد: | 0304-3940 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9903ba6ac26ec249696de022d3751a https://doi.org/10.1016/0304-3940(96)12859-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3b9903ba6ac26ec249696de022d3751a |
| قاعدة البيانات: | OpenAIRE |
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