A randomised controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling
| العنوان: | A randomised controlled trial of biopsy forceps and cannula aspiration for transcervical chorionic villus sampling |
|---|---|
| المؤلفون: | Lynn C. Allen, Greg Ryan, Bernie J.J. Fernandes, Peter von Dadelszen, Mathew Sermer, Joan Hillier, Jo-Ann Johnson, Jerry Shime, Elizabeth J.T. Winsor |
| المصدر: | BJOG: An International Journal of Obstetrics & Gynaecology. 112:559-566 |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | medicine.medical_specialty, Forceps, Chorionic villus sampling, Prenatal diagnosis, Catheterization, Obstetrical Forceps, law.invention, Randomized controlled trial, Pregnancy, law, Biopsy, medicine, Humans, Intention-to-treat analysis, medicine.diagnostic_test, Obstetrics, business.industry, Biopsy, Needle, Pregnancy Outcome, Obstetrics and Gynecology, Equipment Design, Surgical Instruments, Cannula, Fetomaternal Transfusion, Surgery, Chorionic Villi Sampling, Patient Satisfaction, Cytogenetic Analysis, Gestation, Female, alpha-Fetoproteins, business |
| الوصف: | Objective This trial compared two instruments for transcervical chorionic villus sampling (CVS). Design Randomised controlled trial. Setting Regional university prenatal diagnosis and treatment centre. Population Two hundred women were randomised at 10+0–12+6 weeks of gestation to transcervical CVS using cannula aspiration (CA) or biopsy forceps (BF). Methods Women undergoing indicated CVS signed informed consent. Randomisation after decision to perform transcervical CVS. Main outcome measures Primary outcome: the rise in maternal serum α-fetoprotein (α-FP). Secondary outcomes: (i) placental trauma (fetomaternal haemorrhage [FMH]); (ii) laboratory, procedure, and cytogenetic results and pregnancy outcomes; (iii) patient and operator satisfaction; and (iv) economic analyses. Analyses were performed by intention to treat. Results The -FP rise did not differ between groups; there was no other evidence of placental trauma. BF were better tolerated by women, provided culturable tissue, after fewer instrument passes, with greater ease and in less time. BF were associated with cost savings. Conclusions Unlike -FP, other markers of FMH were unaltered, questioning the reliability of α-FP as an indicator of FMH. Compared with CA, transcervical BF caused comparable placental trauma, appeared to be similarly effective and safe and were preferred by operators and patients. |
| تدمد: | 1471-0528 1470-0328 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d0d610a23d9037d11fc3f6de4f72b72 https://doi.org/10.1111/j.1471-0528.2004.00483.x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3d0d610a23d9037d11fc3f6de4f72b72 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14710528 14700328 |
|---|