Nanobacteria: A Possible Etiology for Type III Prostatitis
| العنوان: | Nanobacteria: A Possible Etiology for Type III Prostatitis |
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| المؤلفون: | Zhansong Zhou, Aimin Ming, Xuecheng Shen, Xin Li, Bo Song |
| المصدر: | Journal of Urology. 184:364-369 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Male, Nephrology, medicine.medical_specialty, Pathology, Urology, Interleukin-1beta, Prostatitis, Enzyme-Linked Immunosorbent Assay, Rats, Sprague-Dawley, Random Allocation, Prostate, Internal medicine, medicine, Animals, Pathological, Analysis of Variance, Chi-Square Distribution, Bacteria, Tumor Necrosis Factor-alpha, Genitourinary system, business.industry, medicine.disease, Rats, Rat Prostate, Disease Models, Animal, medicine.anatomical_structure, Etiology, Nanoparticles, Tumor necrosis factor alpha, business |
| الوصف: | Nanobacteria are thought to be a pathopoiesis bacterium in urological disease. We observed pathological changes in nanobacteria infected prostates in Sprague-Dawley(R) rats and investigated the possible etiological relationships of nanobacteria and type III prostatitis.We randomized 40 adult male Sprague-Dawley rats each to the control and model groups. Rat prostate infection models were reproduced by infusing nanobacteria suspension transurethrally. Rats were sacrificed 1, 2, 4 and 8 weeks later, respectively. Prostatic pathology, and the cytokines interleukin-1beta and tumor necrosis factor-alpha were assessed. Nanobacteria isolation, culture and characterization were also analyzed.In model rats we observed prostatic acute inflammatory changes 1 to 2 weeks after nanobacteria infusion and chronic inflammatory changes after 4 weeks. At 8 weeks we noted microcalculous formation in the prostatic glandular cavity in 7 of the 10 model rats, which was not seen in controls. Interleukin-1beta and tumor necrosis factor-alpha in prostatic tissues were higher in model rats than in controls at different time points (p0.01). In model rats interleukin-1beta and tumor necrosis factor-alpha were higher 2 weeks after infusion than at 1, 4 and 8 weeks (p0.05). Prostatic tissue was nanobacteria positive in 35 model rats and in 0 controls.Nanobacteria may be an important etiological factor for type III prostatitis. |
| تدمد: | 1527-3792 0022-5347 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d880ef005365a0ec598017c3ee0ab12 https://doi.org/10.1016/j.juro.2010.03.003 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....3d880ef005365a0ec598017c3ee0ab12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15273792 00225347 |
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