Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes
| العنوان: | Diagnostic Distinction of Malignant Melanoma and Benign Nevi by a Gene Expression Signature and Correlation to Clinical Outcomes |
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| المؤلفون: | Jean Y. Tang, M. Bryan Warf, Kristen Rushton, Jinah Kim, Jennifer S. Ko, Richard J. Wenstrup, Loren E. Clarke, Darl D. Flake, Catherine Miller, Colleen Rock, Jonathan Nelson, Thaylon Davis, Hillary Kimbrell, Kavita Y. Sarin, Balwir Matharoo-Ball, Steven D. Billings, Anne-Renee Hartman, Brian J. Thomson, Emily Y. Cai |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention. 26:1107-1113 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Epidemiology, Sentinel lymph node, Sensitivity and Specificity, Metastasis, Diagnosis, Differential, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Stage (cooking), Melanoma, neoplasms, Aged, Skin, Nevus, Pigmented, business.industry, Gene Expression Profiling, Cancer, Middle Aged, Gene signature, medicine.disease, Dermatology, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Cutaneous melanoma, Cohort, Melanocytes, Female, Transcriptome, business, Follow-Up Studies |
| الوصف: | Background: Histopathologic examination alone can be inadequate for diagnosis of certain melanocytic neoplasms. Recently, a 23-gene expression signature was clinically validated as an ancillary diagnostic test to differentiate benign nevi from melanoma. The current study assessed the performance of this test in an independent cohort of melanocytic lesions against clinically proven outcomes. Methods: Archival tissue from primary cutaneous melanomas and melanocytic nevi was obtained from four independent institutions and tested with the gene signature. Cases were selected according to pre-defined clinical outcome measures. Malignant lesions were defined as stage I–III primary cutaneous melanomas that produced distant metastases (metastatic to sites other than proximal sentinel lymph node(s)) following diagnosis of the primary lesion. Melanomas that were metastatic at the time of diagnosis, all re-excisions, and lesions with Results: Of 239 submitted samples, 182 met inclusion criteria and produced a valid gene expression result. This included 99 primary cutaneous melanomas with proven distant metastases and 83 melanocytic nevi. Median time to melanoma metastasis was 18 months. Median follow-up time for nevi was 74.9 months. The gene expression score differentiated melanoma from nevi with a sensitivity of 93.8% and a specificity of 96.2%. Conclusions: The results of gene expression testing closely correlate with long-term clinical outcomes of patients with melanocytic neoplasms. Impact: Collectively, this provides strong evidence that the gene signature adds valuable adjunctive information to aid in the accurate diagnosis of melanoma. Cancer Epidemiol Biomarkers Prev; 26(7); 1107–13. ©2017 AACR. |
| تدمد: | 1538-7755 1055-9965 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dfb4de0ab64edc1f64cbbd3cb9691de https://doi.org/10.1158/1055-9965.epi-16-0958 |
| رقم الأكسشن: | edsair.doi.dedup.....3dfb4de0ab64edc1f64cbbd3cb9691de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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