Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy
| العنوان: | Real-Time Imaging of Free Radicals for Mitochondria-Targeting Hypoxic Tumor Therapy |
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| المؤلفون: | Ying Tang, Miao-Deng Liu, Ming-Kang Zhang, Meng-Yun Peng, Bo-Ru Xie, Yu Zhang, Chu-Xin Li, Xian-Zheng Zhang, Xiao-Qiang Wang |
| المصدر: | Nano Letters. 18:6804-6811 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Free Radicals, Radical, Metal Nanoparticles, Apoptosis, Mammary Neoplasms, Animal, Bioengineering, Real time imaging, 02 engineering and technology, Mitochondrion, 010402 general chemistry, 01 natural sciences, Mice, Drug Delivery Systems, In vivo, Cell Line, Tumor, medicine, Animals, General Materials Science, Inner mitochondrial membrane, Hypoxic tumor, Chemistry, Mechanical Engineering, General Chemistry, Hypoxia (medical), 021001 nanoscience & nanotechnology, Condensed Matter Physics, In vitro, Mitochondria, Molecular Imaging, 0104 chemical sciences, Cancer research, Tumor Hypoxia, Female, Gold, medicine.symptom, 0210 nano-technology |
| الوصف: | Free radicals have emerged as new-type and promising candidates for hypoxic tumor treatment, and further study of their therapeutic mechanism by real-time imaging is of great importance to explore their biomedical applications. Herein, we present a smart free-radical generator AuNC-V057-TPP for hypoxic tumor therapy; the AuNC-V057-TPP not only exhibits good therapeutic effect under both hypoxic and normoxic conditions but also can monitor the release of free radicals in real-time both in vitro and in vivo. What is more, with the mitochondria-targeting ability, the AuNC-V057-TPP is demonstrated with improved antitumor efficacy through enhanced free radical level in mitochondria, which leads to mitochondrial membrane damage and ATP production reduction and finally induces cancer cell apoptosis. |
| تدمد: | 1530-6992 1530-6984 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7709c8a19a5c3289f58dfba8ea3d52 https://doi.org/10.1021/acs.nanolett.8b02670 |
| رقم الأكسشن: | edsair.doi.dedup.....3e7709c8a19a5c3289f58dfba8ea3d52 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 15306992 15306984 |
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