Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy
| العنوان: | Role of sCD40L in the prediction of super-response to cardiac resynchronization therapy |
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| المؤلفون: | Marla Torres, M Rodríguez Mañero, N Varo Cenarruzabeitia, Joaquín Barba, S Castaño Rodríguez, C Pujol, I. Garcia Bolao, A. Macias Gallego |
| المصدر: | Anales del Sistema Sanitario de Navarra v.44 n.2 2021 SciELO España. Revistas Científicas Españolas de Ciencias de la Salud Universidad de Barcelona |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 2019-20 coronavirus outbreak, medicine.medical_treatment, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Cardiac resynchronization therapy, High sensitive, Cardiac Resynchronization Therapy, Absence of mitral regurgitation, QRS complex, Electrocardiography, medicine, Humans, Heart Failure, sCD40L, Ischemic cardiomyopathy, business.industry, General Medicine, Treatment Outcome, Lateral medial position, Qrs width, Echocardiography, High sensitivity troponin, QRS width, Female, business, Nuclear medicine, Super-response |
| الوصف: | espanolFundamento. Analizar los biomarcadores Interleuquina 6, factor de necrosis tumoral α, sCD40L, troponina T hipersensible, proteina C-reactiva hipersensible y galectina-3 en la prediccion de super-respuesta (SR) a la terapia de resincronizacion cardiaca (TRC), ya que no han sido valorados con anterioridad. Material y metodos. Se recopilaron datos clinicos, electrocardiograficos y ecocardiograficos preimplante y al ano. Se definio SR como disminucion del VTSVI ≥ 30% al ano de seguimiento. Las muestras sanguineas fueron extraidas preimplante. Se realizo regresion logistica multivariante y curvas ROC. Resultados. Se incluyeron 50 pacientes, 23 (46%) fueron SR.Las caracteristicas relacionadas con la SR fueron: ser mujer (35 vs. 11%, p = 0,04), sufrir menos cardiopatia isquemica (13 vs. 63%, p Conclusiones. sCD40L se correlaciona significativamente con SR a la TRC. El QRS, la ausencia de insuficiencia mitral y la posicion lateral media del electrodo son predictores independientes de SR en esta cohorte. English Background. The aim of this paper is to analyze the role of the biomarkers Interleukin 6, Tumoral Necrosis Factor α, sCD40L, high sensitive Troponin T, high sensitive C-Reactive Protein and Galectin-3 in predicting super response (SR) to Cardiac Resynchronization Therapy (CRT), as they have not been studied in this field before. Methods. Clinical, electrocardiographic and echocardiographic data was obtained preimplant and after one year. SR was defined as reduction in LVESV ≥ 30% at one year follow-up. Blood samples were extracted preimplant. Multivariate logistic regression and ROC curves were performed. Results. 50 patients were included, 23 (46%) were SR. Characteristics related to SR were: female (35 vs. 11%, p = 0.04), suffering from less ischemic cardiomyopathy (13 vs. 63%, p Conclusion. sCD40L correlates significantly with SR to CRT. QRS width, absence of mitral regurgitation and lateral medial position of the lead are independent predictors of SR in this cohort. |
| وصف الملف: | text/html |
| تدمد: | 2340-3527 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407d7f72aa1093b70862be9062809f57 https://pubmed.ncbi.nlm.nih.gov/34132247 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....407d7f72aa1093b70862be9062809f57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23403527 |
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