Screening of Stat3 inhibitory effects of Korean herbal medicines in the A549 human lung cancer cell line

التفاصيل البيبلوغرافية
العنوان: Screening of Stat3 inhibitory effects of Korean herbal medicines in the A549 human lung cancer cell line
المؤلفون: Jong-Shik Park, Jinhee Kim, Ok-Sun Bang
المصدر: Integrative Medicine Research
Integrative Medicine Research, Vol 3, Iss 2, Pp 67-73 (2014)
بيانات النشر: Elsevier, 2013.
سنة النشر: 2013
مصطلحات موضوعية: A549 cell, biology, Traditional medicine, Stat3, business.industry, Cancer, Ulmus macrocarpa, Pharmacology, Korean medicine, biology.organism_classification, medicine.disease, lcsh:RZ409.7-999, anticancer, Metastasis, herbal extract, Complementary and alternative medicine, Apoptosis, Survivin, medicine, biology.protein, Bupleurum falcatum, Original Article, STAT3, business, lcsh:Miscellaneous systems and treatments
الوصف: Background The transcription factor signal transducer and activator of transcription 3 (Stat3) is constitutively activated in many human cancers. It promotes tumor cell proliferation, inhibits apoptosis, induces angiogenesis and metastasis, and suppresses antitumor host immune responses. Therefore, Stat3 has emerged as a promising molecular target for cancer therapies. In this study, we evaluated the Stat3-suppressive activity of 38 herbal medicines traditionally used in Korea. Methods Medicinal herb extracts in 70% ethanol were screened for their ability to suppress Stat3 in the A549 human lung cancer cell line. A Stat3-responsive reporter assay system was used to detect intracellular Stat3 activity in extract-treated cells, and Western blot analyses were performed to measure the expression profiles of Stat3-regulated proteins. Results Fifty percent of the 38 extracts possessed at least mild Stat3-suppressive activities (i.e., activity less than 75% of the vehicle control). Ethanol extracts of Bupleurum falcatum L., Taraxacum officinale Weber, Solanum nigrum L., Ulmus macrocarpa Hance, Euonymus alatus Sieb., Artemisia capillaris Thunb., and Saururus chinensis (Lour.) Baill inhibited up to 75% of the vehicle control Stat3 activity level. A549 cells treated with these extracts also had reduced Bcl-xL, Survivin, c-Myc, and Mcl-1 expression. Conclusion Many medicinal herbs traditionally used in Korea contain Stat3 activity-suppressing substances. Because of the therapeutic impact of Stat3 inhibition, these results could be useful when developing novel cancer therapeutics from medicinal herbs.
اللغة: English
تدمد: 2213-4239
2213-4220
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44f52a498c3c6bdd56f5e66218a8078f
http://europepmc.org/articles/PMC5481713
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....44f52a498c3c6bdd56f5e66218a8078f
قاعدة البيانات: OpenAIRE