Burkholderia pseudomallei-induced cell fusion in U937 macrophages can be inhibited by monoclonal antibodies against host cell surface molecules
العنوان: | Burkholderia pseudomallei-induced cell fusion in U937 macrophages can be inhibited by monoclonal antibodies against host cell surface molecules |
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المؤلفون: | Donporn Riyapa, Supaporn Suparak, Mark P. Stevens, Veerachat Muangsombut, Sunee Korbsrisate, Ganjana Lertmemongkolchai, Joanne M. Stevens |
المصدر: | Microbes and Infection. 13:1006-1011 |
بيانات النشر: | Elsevier BV, 2011. |
سنة النشر: | 2011 |
مصطلحات موضوعية: | Burkholderia pseudomallei, medicine.drug_class, Immunology, CD47 Antigen, Fusion Regulatory Protein-1, Biology, Monoclonal antibody, Giant Cells, Microbiology, Cell Fusion, Mice, medicine, Animals, Humans, Host cell surface, Cell fusion, U937 cell, Macrophages, CD47, Antibodies, Monoclonal, U937 Cells, Cadherins, bacterial infections and mycoses, biology.organism_classification, Antibodies, Bacterial, Rats, Infectious Diseases, Giant cell, biology.protein, bacteria, Antibody, E-Selectin |
الوصف: | Burkholderia pseudomallei induces the formation of multinucleated giant cells in cell monolayers. After infection of human macrophage-like U937 cells with B. pseudomallei, addition of monoclonal antibodies against integrin-associated protein (CD47), E-selectin (CD62E), a fusion regulatory protein (CD98), and E-cadherin (CD324) suppressed multinucleated giant cells in a concentration-dependent manner while monoclonal antibodies against other surface molecules did not inhibit fusion despite binding to the cell surface. Flow cytometric analysis showed increased expression of CD47 and CD98, but not CD62E and CD324, upon B. pseudomallei infection. Our data suggest the involvement of specific cellular factors in the process of B. pseudomallei-induced fusion. |
تدمد: | 1286-4579 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c1d6f1da55309ecf75c5833a34bef1 https://doi.org/10.1016/j.micinf.2011.06.007 |
حقوق: | CLOSED |
رقم الأكسشن: | edsair.doi.dedup.....45c1d6f1da55309ecf75c5833a34bef1 |
قاعدة البيانات: | OpenAIRE |
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