Detecting At-Risk Alzheimer’s Disease Cases
| العنوان: | Detecting At-Risk Alzheimer’s Disease Cases |
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| المؤلفون: | Arne Nakling, Knut Waterloo, Kjell Arne Arntzen, Ragna Espenes, Sandra R.R. Tecelão, Svein Ivar Bekkelund, Carl Fredrik Eliassen, Kai Ivar Müller, Gøril Rolfseng Grøntvedt, Lene Pålhaugen, Lisa Flem Kalheim, Bjørn-Eivind Kirsebom, Ina S. Almdahl, Geir Bråthen, Krisztina Kunszt Johansen, Ramune Grambaite, Dag Aarsland, Ane Løvli Stav, Stein Harald Johnsen, Arvid Rongve, Per Selnes, Sigrid Botne Sando, Nikias Siafarikas, Erik Hessen, Tormod Fladby, Eirik Auning, Santiago Timón |
| المصدر: | Fladby, T, Palhaugen, L, Selnes, P, Waterloo, K, Brathen, G, Hessen, E, Almdahl, I S, Arntzen, K-A, Auning, E, Eliassen, C F, Espenes, R, Grambaite, R, Grontvedt, G R, Johansen, K K, Johnsen, S H, Kalheim, L F, Kirsebom, B-E, Muller, K I, Nakling, A E, Rongve, A, Sando, S B, Siafarikas, N, Stav, A L, Tecelao, S, Timon, S, Bekkelund, S I & Aarsland, D 2017, ' Detecting At-Risk Alzheimer's Disease Cases ', JOURNAL OF ALZHEIMERS DISEASE, vol. 60, no. 1, pp. 97-105 . https://doi.org/10.3233/JAD-170231 Journal of Alzheimer's Disease |
| بيانات النشر: | IOS Press, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Apolipoprotein E, Apolipoprotein E4, Disease, Neuropsychological Tests, 0302 clinical medicine, Medicine, Cognitive decline, Aged, 80 and over, Norway, General Neuroscience, amyloid, Cognition, General Medicine, Middle Aged, Alzheimer's disease, apolipoprotein E4, Psychiatry and Mental health, Clinical Psychology, Disease Progression, Female, Alzheimer’s disease, Research Article, Adult, medicine.medical_specialty, cerebrospinal fluid, 03 medical and health sciences, mild cognitive impairment, Alzheimer Disease, Internal medicine, Humans, Dementia, Pathological, Aged, Psychiatric Status Rating Scales, Amyloid beta-Peptides, business.industry, Memory clinic, biomarkers, medicine.disease, Peptide Fragments, 030104 developmental biology, Self Report, subjective cognitive decline, Geriatrics and Gerontology, Cognition Disorders, business, 030217 neurology & neurosurgery |
| الوصف: | While APOE ɛ4 is the major genetic risk factor for Alzheimer’s disease (AD), amyloid dysmetabolism is an initial or early event predicting clinical disease and is an important focus for secondary intervention trials. To improve identification of cases with increased AD risk, we evaluated recruitment procedures using pathological CSF concentrations of Aβ42 (pAβ) and APOE ɛ4 as risk markers in a multi-center study in Norway. In total, 490 subjects aged 40–80 y were included after response to advertisements and media coverage or memory clinics referrals. Controls (n = 164) were classified as normal controls without first-degree relatives with dementia (NC), normal controls with first-degree relatives with dementia (NCFD), or controls scoring below norms on cognitive screening. Patients (n = 301) were classified as subjective cognitive decline or mild cognitive impairment. Subjects underwent a clinical and cognitive examination and MRI according to standardized protocols. Core biomarkers in CSF from 411 and APOE genotype from 445 subjects were obtained. Cases (both self-referrals (n = 180) and memory clinics referrals (n = 87)) had increased fractions of pAβ and APOE ɛ4 frequency compared to NC. Also, NCFD had higher APOE ɛ4 frequencies without increased fraction of pAβ compared to NC, and cases recruited from memory clinics had higher fractions of pAβ and APOE ɛ4 frequency than self-referred. This study shows that memory clinic referrals are pAβ enriched, whereas self-referred and NCFD cases more frequently are pAβ negative but at risk (APOE ɛ4 positive), suitable for primary intervention. |
| وصف الملف: | application/pdf |
| تدمد: | 1875-8908 1387-2877 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a7d7730607572baca51c6bb6c94568 https://doi.org/10.3233/jad-170231 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....46a7d7730607572baca51c6bb6c94568 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758908 13872877 |
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