Application of Candida solubilized cell wall β-glucan in antitumor immunotherapy against P815 mastocytoma in mice
| العنوان: | Application of Candida solubilized cell wall β-glucan in antitumor immunotherapy against P815 mastocytoma in mice |
|---|---|
| المؤلفون: | Noriko N. Miura, Toshiro Yadomae, Naohito Ohno, Yoshiyuki Adachi, Kazuhiro Tokunaka |
| المصدر: | International Immunopharmacology. 2:59-67 |
| بيانات النشر: | Elsevier BV, 2002. |
| سنة النشر: | 2002 |
| مصطلحات موضوعية: | medicine.medical_treatment, Genetic enhancement, Immunology, Mast-Cell Sarcoma, chemical and pharmacologic phenomena, Spleen, Transfection, Immunotherapy, Adoptive, Flow cytometry, Microbiology, Mice, Cell Wall, Tumor Cells, Cultured, medicine, Animals, Immunology and Allergy, Candida albicans, Glucans, Candida, Pharmacology, Mice, Inbred BALB C, biology, medicine.diagnostic_test, Mammary Neoplasms, Experimental, Mastocytoma, Genetic Therapy, Immunotherapy, Flow Cytometry, biology.organism_classification, Acquired immune system, medicine.disease, Combined Modality Therapy, Survival Analysis, medicine.anatomical_structure, Mice, Inbred DBA, B7-1 Antigen, Cancer research, Female, Indicators and Reagents, Neoplasm Transplantation, Plasmids |
| الوصف: | This study was designed to evaluate the antitumor activity of CSBG, purified from the cell wall of Candida albicans IFO1385. First, as an effect of CSBG on P815 mastocytoma, significant prolonged survival and suppression of the tumor growth were observed. Second, the transfer of spleen cells from CSBG-sensitized BALB/c mice to CDF1 mice led to further suppression of tumor growth as well as P815-immunized spleen cells. Third, CSBG enhanced antitumor immunity in gene therapy using B7-1-transfected P815 cells. These results strongly suggest that CSBG enhances the host defense response to tumor due in part to an adjuvant effect. |
| تدمد: | 1567-5769 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c549e02f5bc1242324077cd23e49c00 https://doi.org/10.1016/s1567-5769(01)00148-5 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....4c549e02f5bc1242324077cd23e49c00 |
| قاعدة البيانات: | OpenAIRE |
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