Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo
| العنوان: | Thallium-201 Imaging in Intact Olfactory Sensory Neurons with Reduced Pre-Synaptic Inhibition In Vivo |
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| المؤلفون: | Sadaharu Miyazono, Kazuma Ogawa, Junichi Taki, Hideaki Shiga, Hiroshi Wakabayashi, Masami Kumai, Tomo Hiromasa, Kohshin Washiyama, Tomohiro Noguchi, Takaki Miwa, Seigo Kinuya |
| المصدر: | Molecular Neurobiology |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Tyrosine 3-Monooxygenase, Presynaptic Terminals, Neuroscience (miscellaneous), Neuroimaging, Sensory system, Biology, Olfactory dysfunction, Olfactory transport, Olfactory Receptor Neurons, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, 0302 clinical medicine, In vivo, Rotenone, Internal medicine, medicine, Animals, Dopaminergic interneuron, Mitochondrial respiratory chain complex I, Rats, Wistar, Administration, Intranasal, Tomography, Emission-Computed, Single-Photon, Mice, Inbred ICR, Tyrosine hydroxylase, Dopaminergic Neurons, Dopaminergic, Neural Inhibition, Action potential, Electrophysiological Phenomena, Olfactory bulb, Thallium Radioisotopes, Endocrinology, nervous system, Neurology, chemistry, Nasal administration, Tomography, X-Ray Computed, 030217 neurology & neurosurgery |
| الوصف: | In this study, we determined whether the 201Tl (thallium-201)-based olfactory imaging is affected if olfactory sensory neurons received reduced pre-synaptic inhibition signals from dopaminergic interneurons in the olfactory bulb in vivo. The thallium-201 migration rate to the olfactory bulb and the number of action potentials of olfactory sensory neurons were assessed 3 h following left side nasal administration of rotenone, a mitochondrial respiratory chain complex I inhibitor that decreases the number of dopaminergic interneurons without damaging the olfactory sensory neurons in the olfactory bulb, in mice (6–7 animals per group). The migration rate of thallium-201 to the olfactory bulb was significantly increased following intranasal administration of thallium-201 and rotenone (10 μg rotenone, p = 0.0012; 20 μg rotenone, p = 0.0012), compared with that in control mice. The number of action potentials was significantly reduced in the olfactory sensory neurons in the rotenone treated side of 20 μg rotenone-treated mice, compared with that in control mice (p = 0.0029). The migration rate of thallium-201 to the olfactory bulb assessed with SPECT-CT was significantly increased in rats 24 h after the left intranasal administration of thallium-201 and 100 μg rotenone, compared with that in control rats (p = 0.008, 5 rats per group). Our results suggest that thallium-201 migration to the olfactory bulb is increased in intact olfactory sensory neurons with reduced pre-synaptic inhibition from dopaminergic interneurons in olfactory bulb glomeruli. |
| تدمد: | 1559-1182 0893-7648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2973d704a3759e4c94dc2c3009fa49 https://doi.org/10.1007/s12035-020-02078-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4e2973d704a3759e4c94dc2c3009fa49 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15591182 08937648 |
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