A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET
| العنوان: | A 1-week extension of a ketogenic diet provides a further decrease in myocardial 18F-FDG uptake and a high detectability of myocarditis with FDG-PET |
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| المؤلفون: | Alexandra Clément, Jean-Luc Olivier, Allan Kolodziej, Julien Pierson, Gilles Karcher, Henri Boutley, Sylvain Poussier, Pierre-Yves Marie, Mickael Lhuillier, Fatiha Maskali |
| المساهمون: | Nancyclotep- Experimental Imaging Platform = Plate-forme d'imagerie moléculaire, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Université de Lorraine (UL), Service de Biochimie et Biologie Moléculaire, Nutrition et Métabolisme [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Médecine Nucléaire [Nancy], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy) |
| المصدر: | Journal of Nuclear Cardiology Journal of Nuclear Cardiology, Springer Verlag, 2018, 27 (2), pp.612-618. ⟨10.1007/s12350-018-1404-7⟩ |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Myocarditis, Normal diet, medicine.medical_treatment, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, 18f fdg uptake, 03 medical and health sciences, 0302 clinical medicine, Immune system, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, ComputingMilieux_MISCELLANEOUS, 2. Zero hunger, medicine.diagnostic_test, business.industry, Carbohydrate, medicine.disease, 3. Good health, Endocrinology, Positron emission tomography, Ketone bodies, Cardiology and Cardiovascular Medicine, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Ketogenic diet |
| الوصف: | Short periods of fasting and/or low-carbohydrate diet have been proven beneficial for decreasing the myocardial uptake of 18F-fluorodeoxyglucose (18F-FDG) and enhancing the detection of inflammatory heart diseases by 18F-FDG positron emission tomography (PET). This study aimed at determining whether this benefit is increased when a low-carbohydrate ketogenic diet is prolonged up to 7 days. Wistar rats underwent serial 18F-FDG-PET imaging after an 18-hour fasting period and after 2, 4 and 7 days of a ketogenic diet (3% carbohydrate) and they were compared to rats submitted to the same protocol but with normal diet (44% carbohydrate). The 18F-FDG-PET/ketogenic protocol was also applied in rats with immune myocarditis (injection of porcine cardiac myosin). The 7-day ketogenic diet was associated with (1) a sustained increase in circulating ketone bodies at an equivalent level to that reached after 18-hour fasting, (2) a gradual decrease in 18F-FDG uptake within normal myocardium reaching a lower level compared to fasting at the 7th day (myocardium-to-blood ratios: 1.68 ± 1.02 vs 3.25 ± 1.40, P |
| اللغة: | English |
| تدمد: | 1071-3581 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e820eb40a54d88834c44053498d367d https://hal.univ-lorraine.fr/hal-02448315 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4e820eb40a54d88834c44053498d367d |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 10713581 |
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