Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue
| العنوان: | Naringenin Promotes Thermogenic Gene Expression in Human White Adipose Tissue |
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| المؤلفون: | Jacqueline M. Stephens, Yuan Lin, Frank L. Greenway, Ann A. Coulter, Candida J. Rebello, Frank H. Lau, William D. Johnson |
| المصدر: | Obesity (Silver Spring, Md.) |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, Naringenin, medicine.medical_specialty, Adipose Tissue, White, Endocrinology, Diabetes and Metabolism, Gene Expression, Medicine (miscellaneous), Adipose tissue, 030209 endocrinology & metabolism, White adipose tissue, Carbohydrate metabolism, Article, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Internal medicine, medicine, Animals, Humans, Obesity, 030212 general & internal medicine, Nutrition and Dietetics, Adiponectin, food and beverages, Thermogenesis, Human Adipose Tissue, Thermogenin, 3. Good health, Human Adipocytes, chemistry, Insulin Sensitivity, Flavanones, Adipose triglyceride lipase |
| الوصف: | OBJECTIVE Naringenin, a citrus flavonoid, prevents diet-induced weight gain and improves glucose and lipid metabolism in rodents. There is evidence that naringenin activates brown fat and increases energy expenditure in mice, but little is known about its effects in humans. The goal of this study was to examine the effects of naringenin on energy expenditure in adipose tissue. METHODS Human white adipocyte cultures (hADSC) and abdominal subcutaneous adipose tissue (pWAT) were treated with naringenin for 7 to 14 days. Expression (quantitative real-time polymerase chain reaction, immunoblotting) of candidate genes involved in thermogenesis and glucose metabolism was measured. Oxygen consumption rate was measured in hADSC using a Seahorse flux analyzer. RESULTS In hADSC, naringenin increased expression of the genes associated with thermogenesis and fat oxidation, including uncoupling protein 1 and adipose triglyceride lipase, and key factors associated with insulin sensitivity, including glucose transporter type 4, adiponectin, and carbohydrate-responsive element-binding protein (P |
| تدمد: | 1930-739X 1930-7381 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4efc6faa8416971c77fad6ac3b518f3d https://doi.org/10.1002/oby.22352 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....4efc6faa8416971c77fad6ac3b518f3d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1930739X 19307381 |
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