The histocompatibility system in teleostean fishes: From multiple histocompatibility loci to a major histocompatibility complex
| العنوان: | The histocompatibility system in teleostean fishes: From multiple histocompatibility loci to a major histocompatibility complex |
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| المؤلفون: | R.J.M. Stet, E. Egberts |
| المصدر: | Fish and Shellfish Immunology, 1, 1-16 Fish and Shellfish Immunology 1 (1991) |
| بيانات النشر: | Elsevier BV, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | fish, biology, Vertebrate, chemical and pharmacologic phenomena, General Medicine, Aquatic Science, Major histocompatibility complex, major histocompatibility complex, Homology (biology), law.invention, Histocompatibility, Immune system, Experimentele diermorfologie en celbiologie, Evolutionary biology, law, biology.animal, MHC class I, biology.protein, Environmental Chemistry, Experimental Animal Morphology and Cell Biology, Gene, Polymerase chain reaction |
| الوصف: | To date, there is a large body of evidence suggesting a considerable degree of homology between the teleost immune system, and that of higher vertebrate species. This review aims at assessing this homology with respect to the principal immunoregulatory system known as the major histocompatibility complex (MHC). Historically, allograft rejection and mixed leucocyte reactivity have been the only evidence to support the assumption that teleostean fishes do have an MHC. Unambiguous proof for the presence of an MHC in a particular species, however, can only be obtained through the identification and characterisation of the class I and class II genes and/or gene products proper. Recent data from an exploration of the teleost immune system along these lines, such as the production in carp of alloantisera with MHC class I-like specificity, and the identification of MHC-like genomic sequences by use of the polymerase chain reaction technique, are discussed. The information generated from these experiments will certainly direct future biochemical and functional analyses of the teleostean MHC, with the final prospect of validating its homology to that of higher vertebrate species. |
| وصف الملف: | application/octet-stream; text/html |
| تدمد: | 1050-4648 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5031ae4a9911e96080a0feb88f2671d3 https://doi.org/10.1016/s1050-4648(06)80016-1 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....5031ae4a9911e96080a0feb88f2671d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10504648 |
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