Different Kinetic of Enzymatic Inactivation of Lincomycin and Clindamycin inStaphylococcus aureus
| العنوان: | Different Kinetic of Enzymatic Inactivation of Lincomycin and Clindamycin inStaphylococcus aureus |
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| المؤلفون: | Barcs I |
| المصدر: | Journal of Chemotherapy. 5:215-222 |
| بيانات النشر: | Informa UK Limited, 1993. |
| سنة النشر: | 1993 |
| مصطلحات موضوعية: | 0301 basic medicine, Staphylococcus aureus, medicine.drug_class, 030106 microbiology, Antibiotics, Microbial Sensitivity Tests, medicine.disease_cause, Microbiology, 03 medical and health sciences, Minimum inhibitory concentration, 0302 clinical medicine, Staphylococcus epidermidis, medicine, Pharmacology (medical), Biotransformation, Antibacterial agent, Pharmacology, biology, Clindamycin, Drug Resistance, Microbial, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Nucleotidyltransferases, Erythromycin, Lincomycin, Kinetics, Infectious Diseases, Oncology, 030220 oncology & carcinogenesis, Efflux, medicine.drug |
| الوصف: | Lincosamide inactivation nucleotidylation (Lin) enzyme determined by the pBI109PGL plasmid of Staphylococcus epidermidis exhibits high level resistance to lincomycin but sensitivity to clindamycin by standard susceptibility methods. Substrate profile determination showed clindamycin to be a better substrate for the enzyme than lincomycin. In cultures of the plasmid-harboring strain, the level of clindamycin decreased below the inhibitory concentration in the first 4 hours of incubation but the level of lincomycin persisted longer. The initial extended inhibitory effect of clindamycin is due to better membrane penetrating ability, resulting in a higher intracellular concentration than that of lincomycin. Moreover, energy-dependent reduction in clindamycin uptake, probably due to active efflux of clindamycin but not of lincomycin, was observed. A therapeutic effect of clindamycin is not expected in infections caused by Lin-producer strains because the bacteriostatic effect of the drug is rapidly eliminated after administration. |
| تدمد: | 1973-9478 1120-009X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5031f2c03ef5bdea004d74f0ec6ddadb https://doi.org/10.1080/1120009x.1993.11739235 |
| رقم الأكسشن: | edsair.doi.dedup.....5031f2c03ef5bdea004d74f0ec6ddadb |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 19739478 1120009X |
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