Control of Selectivity in FeCl 3 ‐Catalyzed Aerobic Oxidation of Cycloketones
| العنوان: | Control of Selectivity in FeCl 3 ‐Catalyzed Aerobic Oxidation of Cycloketones |
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| المؤلفون: | Qi Zhao, Yongtao Wang, Yu Wang, Qixuan Hu, Jia Yao, Zeyu Wen, Haoran Li |
| المصدر: | Chemistry – An Asian Journal. 18 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Organic Chemistry, General Chemistry, Biochemistry |
| الوصف: | FeCl3 catalyzed aerobic oxidation of ketones always gives rise to the α-C-C cleavage product, having challenges to afford hydroxyl keto compounds. Here we report an effective control of the main product from keto acid to α-hydroxyl ketone, by reducing the concentration of FeCl3 catalyst, together with the employ of DMSO as the solvent. In addition, mechanistic investigations suggested the same FeCl3-coordinated peroxide intermediate for both hydroxylation and C-C cleavage routes, and emphasize the role of DMSO as both ligand and reductant. This work provides a new approach for selective aerobic oxidation under Lewis acid catalysis. |
| تدمد: | 1861-471X 1861-4728 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5086711260cb96120460b4360a2b0073 https://doi.org/10.1002/asia.202201101 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5086711260cb96120460b4360a2b0073 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1861471X 18614728 |
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