Background/research question: When making evidence-based treatment recommendations in clinical practice, there is often considerable uncertainty regarding the expected effects of interventions for certain patient subgroups or individual patients. While calls for more trials frequently emerge in[for full text, please go to the a.m. URL] Nützliche patientenrelevante Forschung; 21. Jahrestagung des Deutschen Netzwerks Evidenzbasierte Medizin