EMMPRIN: A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis
| العنوان: | EMMPRIN: A Novel Regulator of Leukocyte Transmigration into the CNS in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis |
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| المؤلفون: | Claudia Silva, W. W. Tourtellotte, Smriti M. Agrawal, V. W. Yong |
| المصدر: | The Journal of Neuroscience. 31:669-677 |
| بيانات النشر: | Society for Neuroscience, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Pathology, medicine.medical_specialty, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Matrix metalloproteinase, Mice, Downregulation and upregulation, Cell Movement, Leukocyte Trafficking, Leukocytes, Animals, Humans, Medicine, Glia limitans, Metalloproteinase, business.industry, General Neuroscience, Multiple sclerosis, Experimental autoimmune encephalomyelitis, Brain, Articles, medicine.disease, Matrix Metalloproteinases, Mice, Inbred C57BL, Spinal Cord, Tumor progression, Immunology, Basigin, Female, business |
| الوصف: | Extracellular matrix metalloproteinase inducer (EMMPRIN, CD147) is a member of the Ig superfamily, with various physiological roles including the induction of matrix metalloproteinases (MMPs), leukocyte activation, and tumor progression. In this study, we illustrate a novel involvement of EMMPRIN in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). We found EMMPRIN levels to be upregulated on peripheral leukocytes before onset of EAE clinical signs and on infiltrating leukocytes and resident cells within the CNS in symptomatic mice. In EAE brain sections, EMMPRIN expression was localized with MMP-9 protein and activity. The increased EMMPRIN level was also characteristic of brain samples from MS subjects, particularly in plaque-containing areas. To evaluate the implications of elevated EMMPRIN levels, we treated EAE mice with an EMMPRIN function-blocking antibody and found reduced EAE clinical severity accompanied by decreased CNS parenchymal infiltration of leukocytes. Amelioration of EAE clinical signs by the anti-EMMPRIN antibody was critically dependent on its administration around the period of onset of clinical signs, which is typically associated with significant influx of leukocytes into the CNS. Moreover, the reduction in disease severity in anti-EMMPRIN-treated mice was associated with diminished MMP proteolytic activity at the glia limitans, the final barrier before parenchymal infiltration of leukocytes. Together, our results are the first to emphasize a role for EMMPRIN in MS and EAE, whereby EMMPRIN regulates leukocyte trafficking through increasing MMP activity. These results identify EMMPRIN as a novel therapeutic target in MS. |
| تدمد: | 1529-2401 0270-6474 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::537a79200ace4c25104a98a937e5b2c5 https://doi.org/10.1523/jneurosci.3659-10.2011 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....537a79200ace4c25104a98a937e5b2c5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15292401 02706474 |
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