DNA‐bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma
| العنوان: | DNA‐bound elastase of neutrophil extracellular traps degrades plasminogen, reduces plasmin formation, and decreases fibrinolysis: proof of concept in septic shock plasma |
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| المؤلفون: | Ferhat Meziani, Eduardo Anglés-Cano, Philippe Chafey, Cédric Broussard, Madeleine Riès-Kautt, Julie Helms, Florence Toti, Dayana Barbosa da Cruz, Pascale Gaussem, Lluvia Ramírez Aquino, Laure Stiel, Lucas Cougourdan |
| المصدر: | The FASEB Journal. 33:14270-14280 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Plasmin, medicine.medical_treatment, Extracellular Traps, Biochemistry, Fibrin, 03 medical and health sciences, 0302 clinical medicine, Fibrinolysis, Genetics, medicine, Humans, Platelet, Fibrinolysin, Molecular Biology, Aged, Aged, 80 and over, Disseminated intravascular coagulation, Pancreatic Elastase, biology, Chemistry, Septic shock, Elastase, Plasminogen, Neutrophil extracellular traps, Disseminated Intravascular Coagulation, Middle Aged, medicine.disease, Shock, Septic, Cell biology, 030104 developmental biology, Case-Control Studies, biology.protein, 030217 neurology & neurosurgery, Biotechnology, medicine.drug |
| الوصف: | Activation of platelets and neutrophils in septic shock results in the formation of microvascular clots containing an intricate scaffold of fibrin with neutrophil extracellular traps (NETs) DNA. NETs contain multiple components that might impact endogenous fibrinolysis, resulting in failure to lyse clots in the microcirculation and residual systemic microthrombosis. We propose herein that the reservoir of human neutrophil elastase (HNE) on NETs may directly interfere with the fibrinolytic mechanism |
| تدمد: | 1530-6860 0892-6638 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cdd64bf8f26a32e19f2a9066b6fa01 https://doi.org/10.1096/fj.201901363rrr |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....56cdd64bf8f26a32e19f2a9066b6fa01 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306860 08926638 |
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