Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection
| العنوان: | Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection |
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| المؤلفون: | Li-Lan Kuo, Yan-Chung Lo, Ivonne Melano, Po-Wei Sung, Ni Tien, Wen-Chi Su |
| المصدر: | Viruses Volume 13 Issue 7 Viruses, Vol 13, Iss 1301, p 1301 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Arginine, viruses, 030106 microbiology, Lysine, Virus Attachment, arginine, medicine.disease_cause, Virus Replication, Antiviral Agents, Microbiology, complex mixtures, Virus, Article, 03 medical and health sciences, Viral envelope, Virology, Influenza, Human, antiviral therapy, Influenza A virus, medicine, Humans, influenza A virus, chemistry.chemical_classification, lysine, Chemistry, SARS-CoV-2, Amino Acids, Basic, Virus Uncoating, disease prevention, COVID-19, QR1-502, Amino acid, COVID-19 Drug Treatment, 030104 developmental biology, Infectious Diseases, HEK293 Cells, Viral replication, A549 Cells, Spike Glycoprotein, Coronavirus, Angiotensin-Converting Enzyme 2 |
| الوصف: | Amino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative can efficiently block infection of both viruses in vitro. Furthermore, the arginine ester derivative caused a significant boost in virus infection. Studies on their mechanism of action revealed that the compounds potentially disturb virus uncoating rather than virus attachment and endosomal acidification. Our findings suggest that lysine supplementation and the reduction of arginine-rich food intake can be considered as prophylactic and therapeutic regimens against these viruses while also providing a paradigm for the development of broad-spectrum antivirals. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| DOI: | 10.3390/v13071301 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58b575b95ee5f158aa3e90266c21f3c0 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....58b575b95ee5f158aa3e90266c21f3c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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| DOI: | 10.3390/v13071301 |