Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes
| العنوان: | Distinct genetic landscapes and their clinical implications in younger and older patients with myelodysplastic syndromes |
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| المؤلفون: | Wan‐Hsuan Lee, Chien‐Chin Lin, Yu‐Hung Wang, Chi‐Yuan Yao, Yuan‐Yeh Kuo, Mei‐Hsuan Tseng, Yen‐Ling Peng, Cheng‐An Hsu, Hsun‐I Sun, Yi‐Kuang Chuang, Chia‐Lang Hsu, Feng‐Ming Tien, Cheng‐Hong Tsai, Wen‐Chien Chou, Hsin‐An Hou, Hwei‐Fang Tien |
| المصدر: | Hematological Oncology. |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cancer Research, Oncology, Hematology, General Medicine |
| الوصف: | Myelodysplastic syndromes (MDS) are a group of clinically and genetically diverse diseases that impose patients with an increased risk of leukemic transformation. While MDS is a disease of the elderly, the interplay between aging and molecular profiles is not fully understood, especially in the Asian population. Thus, we compared the genetic landscape between younger and older patients in a cohort of 698 patients with primary MDS to advance our understanding of the distinct pathogenesis and different survival impacts of gene mutations in MDS according to age. We found that the average mutation number was higher in the older patients than younger ones. The younger patients had more WT1 and CBL mutations, but less mutated ASXL1, DNMT3A, TET2, SF3B1, SRSF2, STAG2, and TP53 than the older patients. In multivariable survival analysis, RUNX1 mutations with higher variant allele frequency (VAF) and U2AF1 and TP53 mutations were independent poor prognostic indicators in the younger patients, whereas DNMT3A and IDH2 mutations with higher VAF and TP53 mutations conferred inferior outcomes in the older patients. In conclusion, we demonstrated the distinct genetic landscape between younger and older patients with MDS and suggested that mutations impact survival in an age-depended manner. |
| تدمد: | 1099-1069 0278-0232 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a371f881bad0cd0941e11e73e8ea346 https://doi.org/10.1002/hon.3109 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5a371f881bad0cd0941e11e73e8ea346 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991069 02780232 |
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