Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study
| العنوان: | Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study |
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| المؤلفون: | Massimiliano Scalvenzi, Matteo Megna, Maddalena Napolitano, Giuseppe Monfrecola, Claudia Costa, Milena Cappello |
| المساهمون: | Costa, Claudia, Megna, Matteo, Cappello, Milena, Napolitano, Maddalena, Monfrecola, Giuseppe, Scalvenzi, Massimiliano |
| المصدر: | Giornale Italiano di Dermatologia e Venereologia. 154 |
| بيانات النشر: | Edizioni Minerva Medica, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Skin Neoplasms, Adolescent, Dermoscopy, Dermatology, Epithelioid and spindle cell - dermoscopy - melanoma, Nevus, 2708, Diagnosis, Differential, Lesion, Young Adult, 030207 dermatology & venereal diseases, 03 medical and health sciences, Sex Factors, 0302 clinical medicine, Risk Factors, Nevus, Epithelioid and Spindle Cell, Biomarkers, Tumor, Humans, Medicine, Young adult, Medical diagnosis, Child, Melanoma, Aged, Retrospective Studies, business.industry, Retrospective cohort study, Middle Aged, medicine.disease, Spitz nevus, Melanocytes, Female, medicine.symptom, Differential diagnosis, business |
| الوصف: | Background Many efforts have been spent attempting to define clinical, histopathological and molecular markers for differential diagnosis of Spitz nevus and melanoma. Dermoscopy has been widely used but it may be not always sufficient. Methods A retrospective study was performed evaluating Spitzoid-looking lesions showing symmetry at clinical and dermoscopic examination in patients ≥12 years attending our Clinic from 2004 to 2014. Demographic, clinical and dermoscopic data were assessed for each lesion in order to highlight the most common characteristics which could help the differential diagnosis between Spitz nevus and melanoma when clinical or dermoscopic asymmetry is lacking. Results A total of 760 lesions were excised. 690/760 (90.8%), were identified as typical Spitz nevi, whereas 70/760 lesions (9.2%) consisted of malignant melanocytic lesions. Our study showed that almost 9.2% of clinically and dermoscopically symmetric Spitzoid lesions revealed to be malignant melanocytic lesion. For symmetric Spitzoid looking lesions female sex, clinical palpability, the presence of an inverse network at dermoscopic examination and the involvement of lower limbs were observed as the main factors, which were linked to a higher possibility of being malignant lesions. Conclusions In order to avoid missing diagnoses for malignant melanocytic lesions, this study remarked the importance of preventive excision for all Spitzoid-looking lesions in patients ≥12 years, even if they show symmetry at both clinical and dermoscopic level. |
| تدمد: | 1827-1820 0392-0488 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd64bac7e620726106a2715493bc957 https://doi.org/10.23736/s0392-0488.17.05523-7 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5bd64bac7e620726106a2715493bc957 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18271820 03920488 |
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