Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs
| العنوان: | Hedgehog mediated degradation of Ihog adhesion proteins modulates cell segregation in Drosophila wing imaginal discs |
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| المؤلفون: | Xiaoyan Zheng, Ya Zhang, Ya-Hui Chou, Hai Son Tran, Philip A. Beachy, Agnes Lim, Ganhui Lan, Elaine Y. C. Hsia |
| المصدر: | Nature communications, vol 8, iss 1 Nature Communications Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
| بيانات النشر: | eScholarship, University of California, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Patched, animal structures, Science, 1.1 Normal biological development and functioning, General Physics and Astronomy, Receptors, Cell Surface, Endocytosis, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Underpinning research, Receptors, Wings, Genetics, Compartment (development), Wings, Animal, Animals, Drosophila Proteins, Developmental, Hedgehog Proteins, lcsh:Science, Hedgehog, Body Patterning, Multidisciplinary, Membrane Glycoproteins, Chemistry, Animal, Gene Expression Regulation, Developmental, General Chemistry, Smoothened Receptor, Hedgehog signaling pathway, Cell biology, Imaginal disc, 030104 developmental biology, Gene Expression Regulation, Imaginal Discs, Cell Surface, lcsh:Q, Drosophila, Generic health relevance, Signal transduction, Smoothened, Carrier Proteins, Signal Transduction |
| الوصف: | The Drosophila Hedgehog receptor functions to regulate the essential downstream pathway component, Smoothened, and to limit the range of signaling by sequestering Hedgehog protein signal within imaginal disc epithelium. Hedgehog receptor function requires both Patched and Ihog activity, the latter interchangeably encoded by interference hedgehog (ihog) or brother of ihog (boi). Here we show that Patched and Ihog activity are mutually required for receptor endocytosis and degradation, triggered by Hedgehog protein binding, and causing reduced levels of Ihog/Boi proteins in a stripe of cells at the anterior/posterior compartment boundary of the wing imaginal disc. This Ihog spatial discontinuity may contribute to classically defined cell segregation and lineage restriction at the anterior/posterior wing disc compartment boundary, as suggested by our observations that Ihog activity mediates aggregation of otherwise non-adherent cultured cells and that loss of Ihog activity disrupts wing disc cell segregation, even with downstream genetic rescue of Hedgehog signal response. The range of Hedgehog (Hh) signalling in the Drosophila imaginal disc is limited by Hh/receptor degradation at the anterior/posterior (A/P) compartment boundary. Here, the authors show that degradation is mediated by co-receptor proteins Ihog/Boi, whose cell adhesion functions also contribute to A/P cell segregation. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c97a832d41ea27761a942155de54009 https://escholarship.org/uc/item/3z08x3qh |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5c97a832d41ea27761a942155de54009 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |