التفاصيل البيبلوغرافية
العنوان:
Hypermutation In Pancreatic Cancer
المؤلفون:
Borislav Rusev , Krishna Epari , Peter Bailey , Christopher J. Scarlett , Suzanne Manning , Marina Pajic , Conrad Leonard , Skye McKay , Michael C.J. Quinn , Oliver Hofmann , Margaret A. Tempero , Anthony J. Gill , Nikolajs Zeps , Marc Giry-Laterriere , James G. Kench , Christian Pilarsky , Karin A. Oien , Christine A. Iacobuzio-Donahue , Jennifer P. Morton , Janet Graham , Ilse Rooman , Ehsan Nourbakhsh , Euan J. Dickson , Felicity Newell , Ann-Marie Patch , Sean M. Grimmond , Amber L. Johns , Mark J. Cowley , Timothy J. C. Bruxner , C. Ross Carter , Ivana Cataldo , Rita T. Lawlor , Andrew V. Biankin , David K. Chang , Peter J. Wilson , Christopher L. Wolfgang , Mark Pinese , Roberto Salvia , Karin S. Kassahn , Ralph H. Hruban , Richard D. Schulick , Adnan Nagrial , David Miller , Elizabeth A. Musgrove , Venessa T. Chin , Owen J. Sansom , Ronald S Mead , Angela Chou , Nam Q. Nguyen , J. Lynn Fink , Katia Nones , Craig Nourse , Robert Grützmann , Andreia V. Pinho , Lorraine A. Chantrill , Matthew J. Anderson , Nigel B. Jamieson , Fraser Duthie , Qinying Xu , Stephen H. Kazakoff , Jianmin Wu , Nicola Waddell , Amanda Mawson , Neil D. Merrett , Ivon Harliwong , Andrew Stone , Jaswinder S. Samra , Scott Wood , James R. Eshleman , Jeremy L. Humphris , Vincenzo Corbo , Anirban Maitra , Colin J. McKay , Andrew Barbour , Christopher W. Toon , Aldo Scarpa , Oliver Holmes , Angelika N. Christ , John V. Pearson , Giampaolo Tortora , Nick Waddell , Marc D. Jones , Jane Hair , Senel Idrisoglu , Richard A. Morgan
المساهمون:
Cell Differentiation, Basic (bio-) Medical Sciences, Laboratory for Medical and Molecular Oncology
بيانات النشر:
W.B. Saunders, 2017.
سنة النشر:
2017
مصطلحات موضوعية:
0301 basic medicine , Male , DNA Mutational Analysis , Carcinoma, Pancreatic Ductal/genetics , DNA Mismatch Repair/genetics , medicine.disease_cause , DNA Mismatch Repair , 0302 clinical medicine , Sequencing , Pancreatic Adenocarcinoma , Aged, 80 and over , Mutation , Genome , Gastroenterology , Middle Aged , 3. Good health , MutS Homolog 2 Protein , 030220 oncology & carcinogenesis , Somatic Rearrangement , Cancer Genetics , DNA mismatch repair , Female , MutL Protein Homolog 1 , MutS Homolog 2 Protein/genetics , Carcinoma, Pancreatic Ductal , Adult , DNA repair , Somatic hypermutation , Biology , MLH1 , Proto-Oncogene Proteins p21(ras)/genetics , Proto-Oncogene Proteins p21(ras) , 03 medical and health sciences , Pancreatic cancer , medicine , Humans , Aged , Settore MED/06 - ONCOLOGIA MEDICA , Hepatology , MutL Protein Homolog 1/genetics , Cancer , medicine.disease , Pancreatic Neoplasms/genetics , Pancreatic Neoplasms , 030104 developmental biology , MSH2 , Cancer research , Transcriptome
الوصف:
Pancreatic cancer is molecularly diverse, with few effective therapies. Increased mutation burden and defective DNA repair are associated with response to immune checkpoint inhibitors in several other cancer types. We interrogated 385 pancreatic cancer genomes to define hypermutation and its causes. Mutational signatures inferring defects in DNA repair were enriched in those with the highest mutation burdens. Mismatch repair deficiency was identified in 1% of tumors harboring different mechanisms of somatic inactivation of MLH1 and MSH2. Defining mutation load in individual pancreatic cancers and the optimal assay for patient selection may inform clinical trial design for immunotherapy in pancreatic cancer.
وصف الملف:
application/pdf
اللغة:
English
تدمد:
0016-5085
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2a1ef96273f3a7e69614f488101863 http://hdl.handle.net/10807/171762
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....5e2a1ef96273f3a7e69614f488101863
قاعدة البيانات:
OpenAIRE
Full Text via ClinicalKey 