Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease
| العنوان: | Pellagra encephalopathy as a differential diagnosis for Creutzfeldt-Jakob disease |
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| المؤلفون: | Gabor G. Kovacs, Klára Töro, Eva Keller, Till Voigtländer, Katalin Majtényi, Istvan Kapas |
| المصدر: | Metabolic Brain Disease. 27:231-235 |
| بيانات النشر: | Springer Science and Business Media LLC, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Pathology, Pediatrics, Neurology, Encephalopathy, Biochemistry, Creutzfeldt-Jakob Syndrome, Diagnosis, Differential, Cellular and Molecular Neuroscience, Extrapyramidal symptoms, Pellagra, mental disorders, medicine, Humans, Dementia, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Brain, Electroencephalography, Middle Aged, medicine.disease, Immunohistochemistry, nervous system diseases, 14-3-3 Proteins, Disease Progression, Female, Neurology (clinical), Differential diagnosis, medicine.symptom, business, Myoclonus |
| الوصف: | In the present study we evaluated cases referred as suspected Creutzfeldt-Jakob disease (CJD). Five out of 59 without prion disease showed neuropathological features of pellagra encephalopathy with widespread chromatolytic neurons (age range 40-48 years at death; one woman). These patients presented with a progressive neuropsychiatric disorder lasting for 2 to 24 months. Common symptoms included gait disorder, para- or tetraspasticity, extrapyramidal symptoms, incontinence, and myoclonus. Protein 14-3-3 in the cerebrospinal fluid was examined in a single patient and was positive, allowing the clinical classification as probable sporadic CJD. Pellagra encephalopathy may be considered as a differential diagnosis of CJD including detection of protein 14-3-3. |
| تدمد: | 1573-7365 0885-7490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec91114cc3515b6183f025de346ea6e https://doi.org/10.1007/s11011-012-9308-8 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....5ec91114cc3515b6183f025de346ea6e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737365 08857490 |
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