A randomized, open-label clinical trial using optical coherence tomography to compare two sirolimus-eluting stents, one with a biodegradable polymer and the other with a permanent polymer
| العنوان: | A randomized, open-label clinical trial using optical coherence tomography to compare two sirolimus-eluting stents, one with a biodegradable polymer and the other with a permanent polymer |
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| المؤلفون: | Yundai Chen, Lian Chen, Zhi-jun Sun, Qinhua Jin, Hong-bin Liu, Chang-fu Liu, Feng Tian, Luyue Gai, Jun Guo |
| المصدر: | Molecular Medicine Reports. 7:1191-1196 |
| بيانات النشر: | Spandidos Publications, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Cancer Research, Pathology, medicine.medical_specialty, Intimal hyperplasia, Polymers, medicine.medical_treatment, Biodegradable Plastics, Biochemistry, Optical coherence tomography, Genetics, medicine, Humans, Stent implantation, Molecular Biology, Aged, Sirolimus, chemistry.chemical_classification, medicine.diagnostic_test, business.industry, Coronary Stenosis, Stent, Drug-Eluting Stents, Polymer, Middle Aged, medicine.disease, Biodegradable polymer, Treatment Outcome, Oncology, chemistry, Molecular Medicine, Female, Open label, Tunica Intima, business, Nuclear medicine, Tomography, Optical Coherence, medicine.drug |
| الوصف: | Intimal hyperplasia appears to differ after implanting a drug-eluting stent (DES) with a biodegradable or a permanent polymer. The aim of the present study was to compare biodegradable with permanent polymer DES, since the available data are limited. One hundred patients with de novo coronary artery stenosis were included in this study. The patients were classified into 2 groups: DES with a biodegradable polymer (n=50) and DES with a permanent polymer (n=50). Optical coherence tomography (OCT) examination was performed before and after stent implantation. A follow‑up OCT, performed 1 year after stent implantation, compared the morphologies of intimal hyperplasia in the 2 groups. The frequencies of uncovered stent struts (2.27 vs. 1.87%, P=0.145) and stent strut malapposition (1.9 vs. 2.02%, P=0.655) upon the first-year follow-up were not significantly different. Average neointimal thickness was lower in the biodegradable compared with the permanent polymer group (106.12±80.65 vs. 181.20±146.96 µm, P |
| تدمد: | 1791-3004 1791-2997 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f39b7af7ec766cb82836be93ceea8ab https://doi.org/10.3892/mmr.2013.1313 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....5f39b7af7ec766cb82836be93ceea8ab |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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