Superficial CD34‐positive fibroblastic tumor and PRDM10 ‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases
| العنوان: | Superficial CD34‐positive fibroblastic tumor and PRDM10 ‐rearranged soft tissue tumor are overlapping entities: a comprehensive study of 20 cases |
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| المؤلفون: | Céline Charon-Barra, Damien Geneste, Franck Tirode, Richard A. Carr, Sandrine Paindavoine, Raul Perret, François Le Loarer, Daniel Pissaloux, Michael Michal, Marián Švajdler, Alexandra Meurgey, Jean-Michel Coindre, Marie Karanian, Isabelle Soubeyran, Romain Boidot, Valérie Velasco, Jessica Baud, Noëlle Weingertner |
| المصدر: | Histopathology. 79:810-825 |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Histology, Stromal cell, Adolescent, CD34, Antigens, CD34, Soft Tissue Neoplasms, Biology, Pathology and Forensic Medicine, Young Adult, Biomarkers, Tumor, medicine, Humans, Exome sequencing, Gene Rearrangement, Soft tissue, General Medicine, Fibroblasts, Middle Aged, medicine.disease, Immunohistochemistry, DNA-Binding Proteins, Female, Desmin, Sarcoma, Transcription Factors, Comparative genomic hybridization |
| الوصف: | Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor (PRDM10-STT) are rare mesenchymal tumors. These lesions have clinicopathological similarities, but their relationship remains controversial. This study aimed to characterise a series of cases of SCD34FT and PRDM10-STT.Ten lesions each of SCD34FT and PRDM10-STT were studied using immunohistochemistry, array-comparative genomic hybridisation (aCGH), RNA sequencing and exome sequencing. Tumors mainly occurred in young adults, were generally small ( 5 cm) and arose predominantly in the superficial soft tissues of the lower extremities. Follow-up data were available in 15 cases (SCD34FT, n = 7, median 16 months; PRDM10-STT, n = 8, median 14 months), local recurrences occurred in four cases (SCD34FT, two of 10; PRDM10-STT, two of 10), while no distant spread was documented. Morphologically, tumors were relatively well-circumscribed and composed of sheets and fascicles of spindle and pleomorphic cells showing low mitotic activity ( 1/mm²) without necrosis. Other findings included: granular cell change, lipoblast-like cells, ectatic blood vessels with fibrinous material, myxoid stromal changes, metaplastic bone and increased mitotic activity ( 1/mm²). All tumors diffusely expressed CD34, while pan-keratin and desmin were commonly seen focally. SynCAM3 was diffusely expressed in 12 cases (SCD34FT, n = 5; PRDM10-STT, n = 7), independently of fusion status. aCGH profiles were 'flat' (PRDM10-STT, n = 4; SCD34FT, n = 2) and exome sequencing showed no recurrent pathogenic mutations (PRDM10-STT, n = 2; SCD34FT, n = 4). Overall, the only morphological features seen exclusively in PRDM10-STT were myxoid stromal changes (three of 10) and metaplastic bone (two of 10).We expand the current knowledge on PRDM10-STT and SCD34FT and provide additional evidence for considering them as overlapping entities. |
| تدمد: | 1365-2559 0309-0167 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f238aae7ace84f7c0f1b74c6794482 https://doi.org/10.1111/his.14429 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....60f238aae7ace84f7c0f1b74c6794482 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652559 03090167 |
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