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Two diagnostic criteria of optical spectroscopy for bladder tumor detection: Clinical study using 5-ALA induced fluorescence and mathematical modeling

التفاصيل البيبلوغرافية
العنوان: Two diagnostic criteria of optical spectroscopy for bladder tumor detection: Clinical study using 5-ALA induced fluorescence and mathematical modeling
المؤلفون: Maxim Loshchenov, Victor B. Loschenov, Boris Kudashev, Nina A. Kalyagina, Christian Daul, Marine Amouroux, Walter Blondel
المساهمون: A. M. Prokhorov General Physics Institute (GPI), Russian Academy of Sciences [Moscow] (RAS), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), N.N. Blokhin Russian Cancer Research Center
المصدر: Photodiagnosis and Photodynamic Therapy
Photodiagnosis and Photodynamic Therapy, Elsevier, 2020, 31, pp.101829. ⟨10.1016/j.pdpdt.2020.101829⟩
بيانات النشر: HAL CCSD, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Materials science, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, 030303 biophysics, Biophysics, [SDV.CAN]Life Sciences [q-bio]/Cancer, Dermatology, laser signal, Malignancy, Signal, law.invention, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Nuclear magnetic resonance, law, medicine, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Pharmacology (medical), Urothelium, Spectroscopy, optical spectroscopy, 0303 health sciences, Photosensitizing Agents, Bladder cancer, Spectrum Analysis, scattering, Aminolevulinic Acid, Laser, medicine.disease, diffuse reflectance, Fluorescence, Intensity (physics), Spectrometry, Fluorescence, Photochemotherapy, Urinary Bladder Neoplasms, Oncology, bladder cancer, fluorescence, [SDV.MHEP.DERM]Life Sciences [q-bio]/Human health and pathology/Dermatology, photodynamic diagnosis
الوصف: International audience; Background: The study proposes to improve bladder cancer diagnosis by (i) photodynamic diagnosis (PDD) using red-light excitation (632.8 nm) of 5-ALA induced-protoporphyrin IX in 9 patients’ bladder associated to the analysis of two types of signals to improve the diagnostic accuracy, and (ii) numerical modeling of scattering coefficient for providing biological explanations of the results obtained.Methods: Two modalities of the bladder cancer spectral diagnosis are presented: conventional PDD and intensity assessment of the diffusely reflected laser light by fiber-optic spectroscopy. Experiments are done in clinical conditions and as a series of numerical simulations.Results: High-grade cancerous bladder tissues display twice a higher relative fluorescence intensity (mean value 1, n = 9) than healthy (0.39, n = 9), dysplastic (0.44, n = 5) tissues and CIS (0.39, n = 2). The laser back-scattering signal allows to discriminate most effectively high-grade cancerous and dysplastic tissues from normal. Numerical modeling of diffuse reflectance spectra reveals that spectral behavior of the back-scattered light depends on both, nuclear size and nuclear density of tumoral cells.Conclusions: Unlike the fluorescence signal, where its value is higher in the case of pathological tissues, the tendency of the laser signal to, both, decrease or increase in comparison with the signal from normal urothelium, should be perceived as a sign towards the neoplasm. Numerical simulation reveals that such a double-analysis at a multiwavelength mode potentially may be used to provide diagnostic accuracy.
اللغة: English
تدمد: 1572-1000
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6162619dd0608fd390a1a82ca682c34f
https://hal.archives-ouvertes.fr/hal-02648643
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....6162619dd0608fd390a1a82ca682c34f
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15721000