Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens
| العنوان: | Hairy Cell Leukemia with Systemic Lymphadenopathy: Detection of BRAF Mutations in Both Lymph Node and Peripheral Blood Specimens |
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| المؤلفون: | Tomoyasu Jo, Kazuya Sakai, Hiroyuki Sugiura, Masaru Ide, Kazuya Okada, Yasunori Ueda, Yusuke Okamoto, Taku Tsukamoto, Hiroyuki Matsui, Tomoaki Ueda, Kenji Notohara, Akane Kunitomi, Shinya Kimura, Hiroyuki Muranushi, Tatsuhito Onishi |
| المصدر: | Internal Medicine. 54:1397-1402 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Proto-Oncogene Proteins B-raf, Leukemia, Hairy Cell, Pathology, medicine.medical_specialty, Pancytopenia, business.industry, General Medicine, Neutropenia, medicine.disease, Polymorphism, Single Nucleotide, Peripheral blood, BRAF V600E, Leukemia, medicine.anatomical_structure, Splenomegaly, Internal Medicine, medicine, Humans, Female, Hairy cell leukemia, Lymph Nodes, business, Lymphatic Diseases, Lymph node |
| الوصف: | A 47-year-old woman with pancytopenia, excessive systemic lymphadenopathy and splenomegaly was referred to our hospital. The peripheral blood (PB) smear findings indicated neutropenia with lymphoid cells exhibiting hairy projections, while the histological findings of the cervical lymph node (LN) suggested hairy cell leukemia (HCL). In addition, the BRAF V600E mutation was detected, and the immunoglobulin gene rearrangement patterns were identical in both the cervical LN and PB specimens. Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL. This is the first report of a BRAF mutation detected in both the PB and LN at the onset of HCL. |
| تدمد: | 1349-7235 0918-2918 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61dd4495634c4656bb908e24dcd13c9d https://doi.org/10.2169/internalmedicine.54.2944 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....61dd4495634c4656bb908e24dcd13c9d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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