Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study
| العنوان: | Safety and efficacy of cangrelor in acute stenting for the treatment of cerebrovascular pathology: preliminary experience in a single-center pilot study |
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| المؤلفون: | Eric Sauvageau, Roberta Santos, Manuel F Granja, Douglas Gonsales, Guilherme J. Agnoletto, Pedro Aguilar-Salinas, Ricardo A. Hanel, Amin Aghaebrahim, Leonardo B.C. Brasiliense |
| المصدر: | Journal of NeuroInterventional Surgery. 11:347-351 |
| بيانات النشر: | BMJ, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_treatment, Pilot Projects, Platelet inhibition, Single Center, Brain Ischemia, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cangrelor, Aneurysm, Humans, Medicine, cardiovascular diseases, Stroke, Aged, Thrombectomy, Cerebrovascular pathology, Aged, 80 and over, Aspirin, business.industry, Endovascular Procedures, Stent, General Medicine, Middle Aged, medicine.disease, Adenosine Monophosphate, Treatment Outcome, chemistry, Anesthesia, Purinergic P2Y Receptor Antagonists, Drug Therapy, Combination, Female, Stents, Surgery, Neurology (clinical), business, Platelet Aggregation Inhibitors, 030217 neurology & neurosurgery, Follow-Up Studies, medicine.drug |
| الوصف: | BackgroundTreatment of acute cerebrovascular pathology, such as acute ischemic stroke or intracranial aneurysms, presents a challenge if an extracranial or intracranial stent is required; immediate platelet inhibition is vital. To date, there is no standardized approach for antiplatelet inhibition in an acute setting.ObjectiveTo report our preliminary experience and lessons learnt using cangrelor in acute neurointervention.MethodsA single-arm pilot study was performed to assess the safety and efficacy of cangrelor plus aspirin for platelet inhibition in patients who require acute stenting in the setting of neuroendovascular treatment.ResultsEight patients were enrolled between October 2017 and August 2018. Median age was 71 years (53–86). Seven patients were treated in an acute setting according to the stroke protocol at our institution, while one patient was treated for a symptomatic, unruptured aneurysm with flow diversion and coiling. At admission, the median National Institutes of Health Stroke Scale score for the patients with stroke was 12.5 (range 2–22.3). Cangrelor was infused and all patients achieved adequate platelet inhibition (ConclusionsOur findings suggest that cangrelor is a promising alternative in acute stenting for the treatment of cerebrovascular pathology. However, further studies with larger samples are required to accurately elucidate its safety and effectiveness in neuroendovascular procedures. |
| تدمد: | 1759-8486 1759-8478 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63bbdfc32235b1560534ef6cac404208 https://doi.org/10.1136/neurintsurg-2018-014396 |
| رقم الأكسشن: | edsair.doi.dedup.....63bbdfc32235b1560534ef6cac404208 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17598486 17598478 |
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