Single nucleotide polymorphisms within the Wnt pathway predict the risk of bone metastasis in patients with non-small cell lung cancer
العنوان: | Single nucleotide polymorphisms within the Wnt pathway predict the risk of bone metastasis in patients with non-small cell lung cancer |
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المؤلفون: | Lihong Weng, Junfan Pan, Yusheng Chen, Yanqin Qiu, Yiquan Xu, Hongru Li, Dongmei Zheng, Huaqiang He, Junqiong Zheng, Fan Wu |
المصدر: | Aging (Albany NY) |
بيانات النشر: | Impact Journals, 2020. |
سنة النشر: | 2020 |
مصطلحات موضوعية: | Male, Aging, Lung Neoplasms, Proliferation index, Single-nucleotide polymorphism, Bone Neoplasms, Polymorphism, Single Nucleotide, Wnt signaling pathway, WNT2, Carcinoma, Non-Small-Cell Lung, Genotype, medicine, Biomarkers, Tumor, Humans, Genetic Predisposition to Disease, Lung cancer, beta Catenin, bone metastasis, risk, business.industry, Bone metastasis, Cancer, Cell Biology, Middle Aged, medicine.disease, Cancer research, biomarker, Female, business, polymorphisms, Research Paper |
الوصف: | The Wingless-type (Wnt) signaling pathway plays an important role in the development and progression of cancer. This study aimed to evaluate the relationship between single nucleotide polymorphisms (SNPs) in the Wnt pathway and the risk of bone metastasis in patients with non-small cell lung cancer (NSCLC). We collected 500 blood samples from patients with NSCLC and genotyped eight SNPs from four core genes (WNT2, AXIN1, CTNNB1 and APC) present within the WNT pathway. Moreover, we assessed the potential relationship of these genes with bone metastasis development. Our results showed that the AC/AA genotype of CTNNB1: rs1880481 was associated with a decreased risk of bone metastasis. Polymorphisms with an HR of < 1 had a cumulative protective impact on the risk of bone metastasis. Furthermore, patients with the AC/AA genotype of CTNNB1: rs1880481 was associated with Karnofsky performance status score, squamous cell carcinoma antigen and Ki-67 proliferation index. Lastly, patients with the AC/AA genotype of CTNNB1: rs1880481 had significantly longer median progression free survival time than those with the CC genotype. In conclusion, SNPs within the Wnt signaling pathway are associated with a decreased risk of bone metastasis, and may be valuable biomarkers for bone metastasis in patients with NSCLC. |
اللغة: | English |
تدمد: | 1945-4589 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63df75a0d402637826815bcefc2e8c56 http://europepmc.org/articles/PMC7288946 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....63df75a0d402637826815bcefc2e8c56 |
قاعدة البيانات: | OpenAIRE |
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