Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma
| العنوان: | Typing of biliary tumor thrombus influences the prognoses of patients with hepatocellular carcinoma |
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| المؤلفون: | Shu-Qun Cheng, Zhi-Bo Zhang, Jian-Yin Zhou, Mao-Lin Yan, Jie Shi, Jia-Yi Wu, Yong-Gang Wei, Ju-Xian Sun, Wan Yee Lau, Chang Liu |
| المصدر: | Cancer Biology & Medicine, Vol 18, Iss 3, Pp 808-815 (2021) Cancer Biology & Medicine |
| بيانات النشر: | China Anti-Cancer Association, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Multivariate analysis, Bilirubin, Gastroenterology, surgery, chemistry.chemical_compound, Biliary tumor, Internal medicine, medicine, staging system, Typing, Thrombus, Survival analysis, RC254-282, Common bile duct, business.industry, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hepatocellular carcinoma, medicine.disease, medicine.anatomical_structure, Oncology, chemistry, Hepatocellular carcinoma, biliary tumor thrombus, Original Article, prognosis, business |
| الوصف: | Objective: To establish a new classification of biliary tumor thrombus (BTT). Methods: Overall survival of patients with BTT was first used to determine whether it correlated with current hepatocellular carcinoma staging systems. Univariate and multivariate analyses were used to determine factors affecting the overall survival (OS) to form the basis of our new classification for BTT. Results: All 6 international staging systems showed overlapping survival curves. Univariate followed by multivariate analyses showed that total bilirubin and intrahepatic/extrahepatic BTT were significant risk factors of OS. Based on these data, a new BTT classification was defined as: Type I: intrahepatic BTT; and Type II: extrahepatic BTT involving a common bile duct or common hepatic duct. Type I was further subdivided into type Ia: BTT involving a second-order intrahepatic duct or above, and type Ib: BTT involving a first-order intrahepatic duct. Type II was further subdivided into type IIa and type IIb using a cut-off total bilirubin (TB) > 300 μmol/L. The numbers (percentages) of patients with types I and II BTT were 69 (34.2%) and 133 (65.8%), respectively. The median OS of type I patients was significantly higher than that of type II patients (37.5 months vs. 23.2 months; P = 0.002). Using subgroup analyses, OS outcomes were significantly different between the subgroups of type IIb and type IIa, although there was no significant difference between the type Ia and type Ib subgroups (P = 0.07). Conclusions: A new BTT classification was established to predict prognoses of HCC patients with BTT who underwent liver resection. |
| اللغة: | English |
| تدمد: | 2095-3941 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6424534fe1fddc5390c497115b232fe4 http://www.cancerbiomed.org/index.php/cocr/article/view/1859 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6424534fe1fddc5390c497115b232fe4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20953941 |
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