Serum Ratio of Free Triiodothyronine to Thyroid-Stimulating Hormone: A Novel Index for Distinguishing Graves’ Disease From Autoimmune Thyroiditis
| العنوان: | Serum Ratio of Free Triiodothyronine to Thyroid-Stimulating Hormone: A Novel Index for Distinguishing Graves’ Disease From Autoimmune Thyroiditis |
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| المؤلفون: | Simin Zhang, Meng Li, Linong Ji, Yu Zhu, Zhiyong Wu, Xueyao Han, Lingli Zhou, Wenjia Yang, Wei Liu, Qian Ren, Min Zhang, Chen Wang |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Graves' disease, Endocrinology, Diabetes and Metabolism, Thyrotropin, 030209 endocrinology & metabolism, Trab, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gastroenterology, Thyroid function tests, Autoimmune thyroiditis, Cohort Studies, Diagnosis, Differential, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Thyroid-stimulating hormone, Internal medicine, differential diagnosis, Medicine, Humans, thyrotoxicosis, Original Research, Retrospective Studies, lcsh:RC648-665, Receiver operating characteristic, medicine.diagnostic_test, thyroid function test, business.industry, Thyroiditis, Autoimmune, Retrospective cohort study, autoimmune thyroiditis, Middle Aged, medicine.disease, Graves Disease, 030220 oncology & carcinogenesis, Cohort, Triiodothyronine, Female, business, Graves’ disease, Biomarkers |
| الوصف: | ObjectiveGraves’ disease (GD) and autoimmune thyroiditis (AIT) are two major causes of thyrotoxicosis that require correct diagnosis to plan appropriate treatment. The objectives of this study were to evaluate the usefulness of thyroid-related parameters for distinguishing GD from AIT and identify a novel index for differential diagnosis of thyrotoxicosis.DesignThis retrospective study was performed using electronic medical records in Peking University People’s Hospital (Beijing, China).MethodsIn total, 650 patients with GD and 155 patients with AIT from December 2015 to October 2019 were included in cohort 1. Furthermore, 133 patients with GD and 14 patients with AIT from December 2019 to August 2020 were included in cohort 2 for validation of the novel index identified in cohort 1. All patients were of Chinese ethnicity and were newly diagnosed with either GD or AIT. Thyroid-related clinical information was collected before intervention by reviewing the patients’ electronic medical records. Receiver operating characteristic curve analysis was used to identify the optimal cutoff for distinguishing GD from AIT.ResultsIn cohort 1, thyroid-stimulating hormone (TSH) receptor antibody was identified as the best indicator for distinguishing GD from AIT. The area under the receiver operating characteristic curve was 0.99(95% confidence interval: 0.98–0.99, pConclusionsThe FT3/TSH ratio is a new useful index for differential diagnosis of thyrotoxicosis, especially when combined with TRAb. |
| اللغة: | English |
| تدمد: | 1664-2392 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64802d37ff166f7de3d93048f54ff42c http://europepmc.org/articles/PMC7821852 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....64802d37ff166f7de3d93048f54ff42c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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