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Prenatal exposure to fipronil disturbs maternal aggressive behavior in rats

التفاصيل البيبلوغرافية
العنوان: Prenatal exposure to fipronil disturbs maternal aggressive behavior in rats
المؤلفون: Julia Zaccarelli Magalhães, Helenice de Souza Spinosa, Angélica María Sánchez-Sarmiento, Marcelo Pires Nogueira de Carvalho, Maria Martha Bernardi, Mariana Sayuri Berto Udo
المصدر: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
بيانات النشر: Elsevier BV, 2015.
سنة النشر: 2015
مصطلحات موضوعية: Male, Insecticides, medicine.medical_specialty, Dose, Administration, Oral, Motor Activity, Biology, Toxicology, Open field, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Developmental Neuroscience, Pregnancy, Internal medicine, Lactation, biology.animal, medicine, Animals, Rats, Wistar, Maternal Behavior, Receptor, Fipronil, Cockroach, Dose-Response Relationship, Drug, Glutamate receptor, Rats, Aggression, Endocrinology, medicine.anatomical_structure, chemistry, Prenatal Exposure Delayed Effects, TOXICIDADE EM ANIMAL, Toxicity, Pyrazoles, Female
الوصف: Fipronil is a second-generation phenilpirazol insecticide that is used in agriculture and veterinary medicine for protection against fleas, ticks, ants, cockroaches and other pests. The insecticide blocks the chloride channels associated with the gamma-amino butyric acid (GABA) receptors in mammals and the chloride channels associated with the GABA and glutamate (Glu) receptors in insects. In this study, a commercial product that contain fipronil was administered orally to pregnant Wistar rats at dosages of 0.1, 1.0, or 10.0 mg/kg/day from the 6th to the 20th day of gestation (n=10 pregnant rats/group) to assess the maternal aggressive behavior (on the 6th day of lactation) and the histopathology of the ovaries and the thyroid gland of the dams. The fipronil caused a disturbance of the maternal aggressive behavior; the aggression against a male intruder decreased at the lowest dose, but increased at the highest dose, without interfering with the general activity of the dams in the open field test at either dose. The histopathological analysis revealed no abnormalities. The differential effects of fipronil behavior appeared to be a consequence of actions on central nervous system areas that control these behaviors. We suggest that fipronil acts on maternal aggressive behavior through GABA(A) receptors.
تدمد: 0892-0362
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::650ed69118260f3604246a4a97a2ddd3
https://doi.org/10.1016/j.ntt.2015.09.007
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....650ed69118260f3604246a4a97a2ddd3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:08920362