Modeling of Cognitive Impairment by Disease Duration in Multiple Sclerosis: A Cross-Sectional Study
| العنوان: | Modeling of Cognitive Impairment by Disease Duration in Multiple Sclerosis: A Cross-Sectional Study |
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| المؤلفون: | Micharel Gurevich, Joab Chapman, Anat Achiron, David Magalashvili, Olga Khilkevich, Mark Dolev, Eran Bercovich, Gil Hararai, Yael Stern, Shay Menascu, Glen M. Doniger, M. Lavie, Michael Polliack, Yoram Barak |
| المصدر: | PLoS ONE PLoS ONE, Vol 8, Iss 8, p e71058 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Gerontology, Time Factors, Anatomy and Physiology, Epidemiology, Cross-sectional study, lcsh:Medicine, Social and Behavioral Sciences, Cognition, Cluster Analysis, Psychology, Cognitive decline, lcsh:Science, Cognitive impairment, education.field_of_study, Multidisciplinary, Cognitive Neurology, Neurodegenerative Diseases, Middle Aged, Mental Health, Neurology, Medicine, Female, Research Article, Adult, medicine.medical_specialty, Multiple Sclerosis, Cognitive Neuroscience, Disease duration, Population, Biology, Cognitive neuroscience, Autoimmune Diseases, Physical medicine and rehabilitation, Neuropsychology, Neurorehabilitation and Trauma, medicine, Humans, education, Models, Statistical, Population Biology, Multiple sclerosis, lcsh:R, Cognitive Psychology, Computational Biology, medicine.disease, Demyelinating Disorders, Cross-Sectional Studies, lcsh:Q, Clinical Immunology, Neuroscience |
| الوصف: | Background/Aims Large-scale population studies measuring rates and dynamics of cognitive decline in multiple sclerosis (MS) are lacking. In the current cross-sectional study we evaluated the patterns of cognitive impairment in MS patients with disease duration of up to 30 years. Methods 1,500 patients with MS were assessed by a computerized cognitive battery measuring verbal and non-verbal memory, executive function, visual spatial perception, verbal function, attention, information processing speed and motor skills. Cognitive impairment was defined as below one standard deviation (SD) and severe cognitive impairment as below 2SD for age and education matched healthy population norms. Results Cognitive performance in our cohort was poorer than healthy population norms. The most frequently impaired domains were information processing speed and executive function. MS patients with secondary-progressive disease course performed poorly compared with clinically isolated syndrome, relapsing-remitting and primary progressive MS patients. By the fifth year from disease onset, 20.9% of patients performed below the 1SD cutoff for impairment, p = 0.005, and 6.0% performed below the 2SD cutoff for severe cognitive impairment, p = 0.002. By 10 years from onset 29.3% and 9.0% of patients performed below the 1SD and 2SD cutoffs, respectively, p = 0.0001. Regression modeling suggested that cognitive impairment may precede MS onset by 1.2 years. Conclusions The rates of cognitive impairment in this large sample of MS patients were lower than previously reported and severe cognitive impairment was evident only in a relatively small group of patients. Cognitive impairment differed significantly from expected normal distribution only at five years from onset, suggesting the existence of a therapeutic window during which patients may benefit from interventions to maintain cognitive health. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671cc5351e83ec376a75ed2dc8765221 https://doi.org/10.1371/journal.pone.0071058 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....671cc5351e83ec376a75ed2dc8765221 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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