Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model
| العنوان: | Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model |
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| المؤلفون: | Anna Hillenmayer, Stefan Kassumeh, Nikolaus Luft, Annabel von Studnitz, Christian Wertheimer, Wolfgang J. Mayer, Andreas Ohlmann, Siegfried G. Priglinger |
| المصدر: | BMC Ophthalmology BMC Ophthalmology, Vol 20, Iss 1, Pp 1-7 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, genetic structures, medicine.medical_treatment, Visual Acuity, Intraocular lens, Clareon, Prosthesis Design, Collagen type 1, Collagen Type I, Cataract surgery, lcsh:Ophthalmology, Lens Implantation, Intraocular, Ophthalmology, Capsular bag model, medicine, Humans, Fluorescent Antibody Technique, Indirect, Posterior capsule opacification, Cells, Cultured, Aged, Lenses, Intraocular, Phacoemulsification, business.industry, General Medicine, Capsule Opacification, Middle Aged, AcrySof, eye diseases, Actins, Tissue Donors, Fibronectins, medicine.anatomical_structure, lcsh:RE1-994, Lens (anatomy), Capsular bag, Posterior Capsule of the Lens, sense organs, business, Ex vivo, Research Article |
| الوصف: | BackgroundPosterior capsule opacification (PCO) after cataract surgery is influenced by intraocular lens (IOL) design and material. The following is an ex vivo comparison of PCO between the Clareon vs. the AcrySof IOL in human capsular bags.MethodsTwenty cadaver capsular bags from 10 human donors were used, with the novel hydrophobic IOL (Clareon, CNA0T0) being implanted in one eye and the other eye of the same donor receiving the AcrySof IOL (SN60WF) following phacoemulsification cataract surgery. Five capsular bags of 3 donors served as controls without IOL. Cellular growth of lens epithelial cells was photo-documented daily. The primary endpoint was the time until full coverage of the posterior capsule by cells. Furthermore, immunofluorescence staining of capsular bags for the fibrotic markers f-actin, fibronectin, alpha smooth muscle actin, and collagen type 1 were performed.ResultsThe new Clareon IOL did not show any disadvantages in terms of days until full cell coverage of the posterior capsule in comparison to the AcrySof (p > 0.99). Both, the Clareon (p = 0.01, 14.8 days) and the AcrySof IOL (p = 0.005, 15.7 days) showed a slower PCO development in comparison to the control (8.6 days). The fibrotic markers f-actin, fibronectin, alpha smooth muscle actin, and collagen type 1 were equally distributed between the two IOLs and differed from the control.ConclusionsA comparable performance has been found in the ex vivo formation of PCO between the two IOLs. Long-term clinical studies are necessary to reach final conclusions. |
| تدمد: | 1471-2415 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e7835d31bb9b9f5d3ef1c1501c5265 https://pubmed.ncbi.nlm.nih.gov/32103739 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....69e7835d31bb9b9f5d3ef1c1501c5265 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14712415 |
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