Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations
| العنوان: | Quantitative measurements in the human hippocampus and related areas: correspondence between ex-vivo MRI and histological preparations |
|---|---|
| المؤلفون: | Antonio Viñuela, Alicia Mohedano-Moriano, José Carlos Delgado-González, Ricardo Insausti, A. M. Insausti, Teresa Tuñón-Alvarez, Emilio Artacho-Pérula, M. Cruz, Francisco Mansilla-Legorburo, José Florensa-Vila |
| المساهمون: | Universidad Pública de Navarra. Departamento de Ciencias de la Salud, Nafarroako Unibertsitate Publikoa. Osasun Zientziak Saila, Universidad de Cantabria |
| المصدر: | Academica-e: Repositorio Institucional de la Universidad Pública de Navarra Universidad Pública de Navarra PLoS ONE PLoS ONE, Vol 10, Iss 6, p e0130314 (2015) UCrea Repositorio Abierto de la Universidad de Cantabria Universidad de Cantabria (UC) Academica-e. Repositorio Institucional de la Universidad Pública de Navarra instname |
| بيانات النشر: | Public Library of Science, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, lcsh:Medicine, Splenium, Hippocampus, Biology, Corpus callosum, Lateralization of brain function, Corpus Callosum, Temporal lobe, White matter, symbols.namesake, medicine, Humans, lcsh:Science, Aged, Aged, 80 and over, Brain Mapping, Multidisciplinary, Medial temporal lobe structures, medicine.diagnostic_test, lcsh:R, Histological Techniques, Neurodegenerative Diseases, Magnetic resonance imaging, Anatomy, Histological preparations, Middle Aged, Magnetic Resonance Imaging, Temporal Lobe, Ex-vivo MRI, medicine.anatomical_structure, Case-Control Studies, Nissl body, symbols, lcsh:Q, Female, Research Article |
| الوصف: | The decrease of volume estimates in different structures of the medial temporal lobe related to memory correlate with the decline of cognitive functions in neurodegenerative diseases. This study presents data on the association between MRI quantitative parameters of medial temporal lobe structures and their quantitative estimate in microscopic examination. Twelve control cases had ex-vivo MRI, and thereafter, the temporal lobe of both hemispheres was sectioned from the pole as far as the level of the splenium of the corpus callosum. Nissl stain was used to establish anatomical boundaries between structures in the medial temporal lobe. The study included morphometrical and stereological estimates of the amygdaloid complex, hippocampus, and temporal horn of the lateral ventricle, as well as different regions of grey and white matter in the temporal lobe. Data showed a close association between morphometric MRI images values and those based on the histological determination of boundaries. Only values in perimeter and circularity of the piamater were different. This correspondence is also revealed by the stereological study, although irregular compartments resulted in a lesser agreement. Neither age (< 65 yr and > 65yr) nor hemisphere had any effect. Our results indicate that ex-vivo MRI is highly associated with quantitative information gathered by histological examination, and these data could be used as structural MRI biomarker in neurodegenerative diseases. This study was funded by the Spanish Ministry of Science and Innovation I+D+i Project BFU-2009-14705 (EAP and RI), the Education, Culture and Sports of Castilla-La Mancha Autonomic Government Project PPII-2014-013-A (EAP and RI), and from the Health Research Foundation of Castilla- La Mancha (FISCAM) Project PI-2007-59. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e98ac616df9bbcfd5a25cc2b0b1698 https://hdl.handle.net/2454/30550 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....69e98ac616df9bbcfd5a25cc2b0b1698 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |