Physiological functions of FBW7 in cancer and metabolism
العنوان: | Physiological functions of FBW7 in cancer and metabolism |
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المؤلفون: | Naoe Taira Nihira, Kouhei Shimizu, Hiroyuki Inuzuka, Wenyi Wei |
المصدر: | Cellular signalling. 46 |
سنة النشر: | 2017 |
مصطلحات موضوعية: | 0301 basic medicine, F-Box-WD Repeat-Containing Protein 7, Biology, Article, law.invention, 03 medical and health sciences, Mice, Ubiquitin, In vivo, law, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Phosphorylation, Tumor Suppressor Proteins, Cell Cycle, Ubiquitination, Cancer, Cell Differentiation, Cell Biology, Metabolism, medicine.disease, In vitro, Cell biology, Ubiquitin ligase, 030104 developmental biology, biology.protein, Suppressor, Stem cell, Signal Transduction |
الوصف: | FBW7 is one of the most well characterized F-box proteins that serve as substrate recognition subunits of SCF (Skp1-Cullin 1-F-box proteins) E3 ubiquitin ligase complexes. SCF(FBW7) plays key roles in regulating cell cycle progression, differentiation, and stem cell maintenance largely through targeting a broad range of oncogenic substrates for proteasome-dependent degradation. The identification of an increasing number of FBW7 substrates for ubiquitination, and intensive in vitro and in vivo studies have revealed a network of signaling components controlled by FBW7 that contributes to metabolic regulation as well as its tumor suppressor role. Here we mainly focus on recent findings that highlight a critical role for FBW7 in cancer and metabolism. |
تدمد: | 1873-3913 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab4002f8699799ca8587814d6f0d218 https://pubmed.ncbi.nlm.nih.gov/29474981 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....6ab4002f8699799ca8587814d6f0d218 |
قاعدة البيانات: | OpenAIRE |
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