Retinal Angiogenesis Regulates Astrocytic Differentiation in Neonatal Mouse Retinas by Oxygen Dependent Mechanisms
| العنوان: | Retinal Angiogenesis Regulates Astrocytic Differentiation in Neonatal Mouse Retinas by Oxygen Dependent Mechanisms |
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| المؤلفون: | Guo-Hua Fong, Thomas N. Sato, Li-Juan Duan, Sarah J. Pan |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Angiogenesis, Neurogenesis, Cellular differentiation, Optic Disk, Neovascularization, Physiologic, lcsh:Medicine, Hyperoxia, Retinal Neovascularization, Article, Retina, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, lcsh:Science, Multidisciplinary, Neovascularization, Pathologic, Chemistry, Stem Cells, lcsh:R, Retinal Vessels, Cell Differentiation, Retinal, Vascular Endothelial Growth Factor Receptor-2, Cell biology, Oxygen, Endothelial stem cell, 030104 developmental biology, medicine.anatomical_structure, Animals, Newborn, Hypoxia-inducible factors, Astrocytes, Optic nerve, lcsh:Q, medicine.symptom, 030217 neurology & neurosurgery, Astrocyte |
| الوصف: | In mice, retinal vascular and astrocyte networks begin to develop at birth, expanding radially from the optic nerve head (ONH) towards the retinal periphery. The retinal vasculature grows towards the periphery ahead of differentiated astrocytes, but behind astrocytic progenitor cells (APCs) and immature astrocytes. Endothelial cell specific Vegfr-2 disruption in newborn mice not only blocked retinal vascular development but also suppressed astrocytic differentiation, reducing the abundance of differentiated astrocytes while causing the accumulation of precursors. By contrast, retinal astrocytic differentiation was accelerated by the exposure of wild-type newborn mice to hyperoxia for 24 hours, or by APC specific deficiency in hypoxia inducible factor (HIF)−2α, an oxygen labile transcription factor. These findings reveal a novel function of the retinal vasculature, and imply that in normal neonatal mice, oxygen from the retinal circulation may promote astrocytic differentiation, in part by triggering oxygen dependent HIF-2α degradation in astrocytic precursors. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c188e76b6be48aa717af70e84011f9b http://link.springer.com/article/10.1038/s41598-017-17962-2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6c188e76b6be48aa717af70e84011f9b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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