Heritability of tic disorders: a twin-family study
| العنوان: | Heritability of tic disorders: a twin-family study |
|---|---|
| المؤلفون: | Rodrigues Zilhao Nogueira, Nuno, Olthof, M C, Smit, D J A, Cath, D C, Ligthart, L, Mathews, C A, Delucchi, K, Boomsma, D I, Dolan, C V, Leerstoel Hout, Experimental psychopathology |
| المساهمون: | Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Biological Psychology, APH - Personalized Medicine, APH - Mental Health, APH - Methodology, Adult Psychiatry, Leerstoel Hout, Experimental psychopathology |
| المصدر: | Psychological Medicine, 47(6), 1085-1096. Cambridge University Press Psychological Medicine, 47(6), 1085. NLM (Medline) Rodrigues Zilhao Nogueira, N, Olthof, M C, Smit, D J A, Cath, D C, Ligthart, L, Mathews, C A, Delucchi, K, Boomsma, D I & Dolan, C V 2017, ' Heritability of tic disorders : a twin-family study ', Psychological Medicine, vol. 47, no. 6, pp. 1085-1096 . https://doi.org/10.1017/S0033291716002981 Psychological medicine, 47(6), 1085-1096. Cambridge University Press Psychological medicine, vol 47, iss 6 |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Netherlands Twin Register (NTR), Male, Tic disorder, Neurodegenerative, heritability, Behavioral syndrome, DSM, 0302 clinical medicine, 80 and over, Psychology, Registries, Child, Applied Psychology, Netherlands, Psychiatry, Aged, 80 and over, tic symptoms, Middle Aged, Pedigree, Psychiatry and Mental health, Mental Health, Public Health and Health Services, Female, Adult, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Tics, Adolescent, Tourette's syndrome, Biology, Dizygotic twins, structural equation modeling, Structural equation modeling, Article, Nuclear Family, 03 medical and health sciences, Young Adult, SDG 3 - Good Health and Well-being, mental disorders, medicine, Genetics, Journal Article, Humans, Genetic Predisposition to Disease, Aged, Assortative mating, Human Genome, Neurosciences, Heritability, medicine.disease, Confidence interval, 030227 psychiatry, Brain Disorders, Tic Disorders, human activities, 030217 neurology & neurosurgery, Demography, Tourette Syndrome |
| الوصف: | BackgroundGenetic–epidemiological studies that estimate the contributions of genetic factors to variation in tic symptoms are scarce. We estimated the extent to which genetic and environmental influences contribute to tics, employing various phenotypic definitions ranging between mild and severe symptomatology, in a large population-based adult twin-family sample.MethodIn an extended twin-family design, we analysed lifetime tic data reported by adult mono- and dizygotic twins (n= 8323) and their family members (n= 7164; parents and siblings) from 7311 families in the Netherlands Twin Register. We measured tics by the abbreviated version of the Schedule for Tourette and Other Behavioral Syndromes. Heritability was estimated by genetic structural equation modeling for four tic disorder definitions: three dichotomous and one trichotomous phenotype, characterized by increasingly strictly defined criteria.ResultsPrevalence rates of the different tic disorders in our sample varied between 0.3 and 4.5% depending on tic disorder definition. Tic frequencies decreased with increasing age. Heritability estimates varied between 0.25 and 0.37, depending on phenotypic definitions. None of the phenotypes showed evidence of assortative mating, effects of shared environment or non-additive genetic effects.ConclusionsHeritabilities of mild and severe tic phenotypes were estimated to be moderate. Overlapping confidence intervals of the heritability estimates suggest overlapping genetic liabilities between the various tic phenotypes. The most lenient phenotype (defined only by tic characteristics, excluding criteria B, C and D of DSM-IV) rendered sufficiently reliable heritability estimates. These findings have implications in phenotypic definitions for future genetic studies. |
| وصف الملف: | application/pdf |
| تدمد: | 1469-8978 0033-2917 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb4ce5bfe878a8cad1658df91b5a9c1 https://pubmed.ncbi.nlm.nih.gov/27974054 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6cb4ce5bfe878a8cad1658df91b5a9c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698978 00332917 |
|---|