Influence of Disease Manifestations on Health-related Quality of Life in Early Psoriatic Arthritis
| العنوان: | Influence of Disease Manifestations on Health-related Quality of Life in Early Psoriatic Arthritis |
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| المؤلفون: | K. Wervers, Cathelijne W. Y. Appels, Johanna M. W. Hazes, Lindy-Anne Korswagen, Marijn Vis, Josien J. Veris-van Dieren, Wiebo L. van der Graaff, Marc R. Kok, Johannes H L M van Groenendael, Andreas H. Gerards, Ilja Tchetverikov, Jolanda J. Luime |
| المساهمون: | Rheumatology |
| المصدر: | Journal of Rheumatology, 45(11), 1526-1531. Journal of Rheumatology |
| بيانات النشر: | Journal of Rheumatology, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Immunology, Arthritis, Enthesopathy, Dactylitis, Cohort Studies, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Rheumatology, Internal medicine, Psoriasis, medicine, Back pain, Immunology and Allergy, Humans, 030212 general & internal medicine, Netherlands, 030203 arthritis & rheumatology, Oligoarthritis, business.industry, Arthritis, Psoriatic, Enthesitis, Middle Aged, medicine.disease, Quality of Life, Polyarthritis, Female, medicine.symptom, business |
| الوصف: | Objective.Psoriatic arthritis (PsA) is a multifaceted disease. Affecting joints, skin, entheses, and dactylitis, its effect on health-related quality of life (HRQOL) could be substantial. We aim to assess HRQOL in patients newly diagnosed with PsA and analyze its associations with disease manifestations.Methods.Data collected at time of diagnosis from patients with PsA included in the Dutch south-west Early Psoriatic Arthritis cohort (DEPAR) study were used. HRQOL was assessed using 8 domains of the Medical Outcomes Study Short Form-36 (SF-36) questionnaire. Patients were classified based on primary manifestation in arthritis subtypes (i.e., mono-, oligo-, or polyarthritis) and other subtypes (i.e., enthesitis, dactylitis, and axial disease). In all patients, presence of arthritis, enthesitis, dactylitis, psoriasis, and chronic inflammatory back pain was determined. Multivariable linear regression was used to determine associations of PsA manifestations with HRQOL.Results.Of 405 patients, primary manifestation was peripheral arthritis in 320 (78 monoarthritis, 151 oligoarthritis, and 91 polyarthritis), enthesitis in 37, axial disease in 9, and dactylitis in 39. Mean scores of SF-36 domains were lower than the Dutch reference population and similar across arthritis subtypes. A higher number of enthesitis locations and tender joints, and presence of chronic back pain, were independently associated with worse SF-36 scores. Psoriasis and dactylitis were not associated with worse scores.Conclusion.HRQOL was diminished in PsA at time of diagnosis compared to the Dutch reference population, and tender joints, enthesitis at clinical examination, and back pain as indicators of pain affected HRQOL. |
| تدمد: | 1499-2752 0315-162X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db68cb59e147eed0da1879f219e125b https://pure.eur.nl/en/publications/88ab431e-c0ee-4fa1-96a1-d131ee10c826 |
| حقوق: | RESTRICTED |
| رقم الأكسشن: | edsair.doi.dedup.....6db68cb59e147eed0da1879f219e125b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14992752 0315162X |
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