Hippocampal Structure and Function in Individuals with Bipolar Disorder: A Systematic Review
| العنوان: | Hippocampal Structure and Function in Individuals with Bipolar Disorder: A Systematic Review |
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| المؤلفون: | Mara Otten, Martijn Meeter |
| المساهمون: | Cognitive Psychology |
| المصدر: | Journal of Affective Disorders, 113-125. Elsevier ISSUE=173;STARTPAGE=113;ENDPAGE=125;ISSN=0165-0327;TITLE=Journal of Affective Disorders Otten, M & Meeter, M 2015, ' Hippocampal Structure and Function in Individuals with Bipolar Disorder: A Systematic Review ', Journal of Affective Disorders, no. 173, pp. 113-125 . https://doi.org/10.1016/j.jad.2014.11.001 Journal of Affective Disorders, 174, 113. Elsevier |
| بيانات النشر: | Elsevier, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Adolescent, Bipolar disorder, EARLY-ONSET, (f)MRI, TEMPORAL-LOBE STRUCTURES, PREFRONTAL CORTEX, Hippocampal formation, Neuroprotection, Hippocampus, I DISORDER, SDG 3 - Good Health and Well-being, Functional neuroimaging, Memory, TERM LITHIUM TREATMENT, SCHIZOPHRENIA, medicine, Humans, Prefrontal cortex, Declarative memory, Functional Neuroimaging, Voxel-based morphometry, Organ Size, medicine.disease, COGNITIVE IMPAIRMENT, Magnetic Resonance Imaging, Hippocampal structure, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Neuroprotective Agents, VOXEL-BASED MORPHOMETRY, Lithium Compounds, Psychology, EUTHYMIC PATIENTS, Neuroscience, Antipsychotic Agents, DECLARATIVE MEMORY |
| الوصف: | Introduction: Bipolar disorder (BD) is a psychiatric disorder accompanied by deficits in declarative memory. Given the importance of the hippocampus in declarative memory, it is not surprising that BD patients have been reported to show hippocampal abnormalities. Objectives: Review evidence about structural and functional hippocampal abnormalities in BD. Methods: Systematic review of studies comparing BD patients and healthy controls with respect to hippocampal structure or function. Results: Twenty-five studies were included, together involving 1043 patients, 21 of which compared patients to controls. Decrease in hippocampal volume was found in four of 18 studies using adult samples, and two of three samples using adolescents. Four studies revealed localized hippocampal deficits. Meta-analysis revealed a significant but small effect with lower hippocampal volumes when comparing all BD patients with controls. Lithium treatment was associated with larger hippocampal volumes across studies. The three functional studies yielded contradictory evidence. Limitations: Studies were only cross-sectional in nature and all used MRI or fMRI to investigate hippocampal volume or function. Heterogeneous patients groups and different methodologies for hippocampal segmentation, may have contributed to difficulties when comparing the different studies. Conclusions: There seems to be a small reduction in hippocampal volume in BD, which perhaps is more pronounced in early-onset BD and is counteracted by a neuroprotective effect of lithium treatment. However, how these structural abnormalities relate to functional deficits is largely unclear. Given the few functional neuroimaging studies and given the lack of congruence in these results, further investigation of especially hippocampal function in BD is recommended. (C) 2014 Elsevier B.V. All rights reserved. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1573-2517 0165-0327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb7ca58f49cb56dc967d5d11bf43a62 https://doi.org/10.1016/j.jad.2014.11.001 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....6eb7ca58f49cb56dc967d5d11bf43a62 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 15732517 01650327 |
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