Rheological Studies Dedicated to the Development of a Novel Injectable Polymeric Blend for Viscosupplementation Treatment
| العنوان: | Rheological Studies Dedicated to the Development of a Novel Injectable Polymeric Blend for Viscosupplementation Treatment |
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| المؤلفون: | G. De Conti, Romano Lapasin, Francesco Segatti, David Mercuri, S. Fusi, C. Spagnul |
| المصدر: | Chemical and Biochemical Engineering Quarterly Volume 29 Issue 4 |
| بيانات النشر: | Croatian Society of Chemical Engineers, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Polymer science, Chemistry, Process Chemistry and Technology, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, amidated carboxymethylcellulose, viscosupplementation, polymeric blend, hydrogel, rheology, Biochemistry, 020401 chemical engineering, Rheology, Polymer chemistry, Viscosupplementation, 0204 chemical engineering, 0210 nano-technology |
| الوصف: | Viscosupplementation is an intra-articular symptomatic treatment of mild osteoarthritis. The treatment involves the injection of high-molecular-weight hyaluronan (HA), and especially of cross-linked HA to restore the lubricating and cushioning properties of the synovial fluid. This work involves the development of a novel viscosupplementation fluid based on amidated carboxymethylcellulose and obtained by blending the soluble polymer with its crosslinked derivative. Rheological analyses carried out under both oscillatory and continuous shear provided a rationale to assess the viscosupplement formulation and the production process. The hydrogel fraction content and the total polymer concentration can be properly selected in order to ensure an optimal combination of flowability and viscoelastic properties. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1846-5153 0352-9568 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f1141f7b96b9cd43b8f2ff57ee4575 https://hrcak.srce.hr/file/221652 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....71f1141f7b96b9cd43b8f2ff57ee4575 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18465153 03529568 |
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