The Relationship Between Enlarged Perivascular Spaces and Cognitive Function: A Meta-Analysis of Observational Studies
| العنوان: | The Relationship Between Enlarged Perivascular Spaces and Cognitive Function: A Meta-Analysis of Observational Studies |
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| المؤلفون: | Zhou Liu, Mingqian Ou, Wanxin Jie, Guanghong Lin, Lifeng Lin, Haihong Zhou, Guocong Liang, Meijun Lin |
| المصدر: | Frontiers in Pharmacology, Vol 11 (2020) Frontiers in Pharmacology |
| بيانات النشر: | Frontiers Media SA, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, 03 medical and health sciences, 0302 clinical medicine, cohort studies, Internal medicine, Medicine, Pharmacology (medical), Perivascular space, Pharmacology, impaired cognition, medicine.diagnostic_test, business.industry, lcsh:RM1-950, odds ratio (OR), Magnetic resonance imaging, Cognition, Odds ratio, Publication bias, enlarged perivascular spaces (ePVS), meta-analysis, lcsh:Therapeutics. Pharmacology, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Meta-analysis, Cardiology, Observational study, Systematic Review, business, Cohort study |
| الوصف: | Enlarged perivascular spaces (ePVS), visible on magnetic resonance imaging (MRI), are associated with aortic pulse wave changes produced by arterial stiffening. However, the relationship between ePVS and cognition is still unclear. We aimed to benchmark current knowledge of associations between ePVS and cognitive function using a meta-analysis of all available published data. We searched three databases for studies examining enlarged perivascular spaces and cognition, identified 7 studies involving 7,816 participants, plotted multivariate-adjusted odds ratio (OR) and 95% CI and generated summary odds ratio (OR) with a fixed effects model. Enlarged perivascular spaces were related to the risk of impaired cognition (OR = 1.387, 95% CI = 1.198-1.606, I2 = 32.6%) with low heterogeneity. There was publication bias, which could be corrected by trimming and supplementation (OR=1.297, 95% CI= 1.130-1.490).EPVS were associated with impaired cognition and may be a sign of cognitive impairment rather than particular diseases. More studies are required to validate ePVS as a measurable risk marker for cognition using consistent methods to determine a characteristic appearance of ePVS . |
| تدمد: | 1663-9812 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73fb7b3ae2df2abfe0d8d5ba32dc285c https://doi.org/10.3389/fphar.2020.00715 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....73fb7b3ae2df2abfe0d8d5ba32dc285c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16639812 |
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