SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases
| العنوان: | SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases |
|---|---|
| المؤلفون: | Gonzalo Ferreira, Mariana Guirado, Garth L. Nicolson, Florencia Savio, Axel Santander, Luis Sobrevia |
| المساهمون: | Universidad de la República, Pontificia Universidad Católica de Chile, Universidad de Sevilla, Universidade Estadual Paulista (UNESP), University of Queensland, University Medical Center Groningen (UMCG), The Institute for Molecular Medicine |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Biochimica et Biophysica Acta. Molecular Basis of Disease Biochimica et Biophysica Acta-Molecular Basis of Disease, 1867(12):166264. ELSEVIER SCIENCE BV |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | E, Envelope, Human pathogen, βCoV, Betacoronavirus, medicine.disease_cause, ENac, Epithelial sodium channel, Zika virus, pp1b, Polyproteins 1b, Mycoplasma, ɣCoV, Gammacoronavirus, N, Nucleocapsid, Pregnancy, Pandemic, HCQ, Hydroxychloroquine, TNF-α, Tumor necrosis factor-α, CQ, Chloroquine, M, Membrane, COVID-19, Coronavirus disease 2019, biology, J-H, Jarisch-Herxheimer reactions, Transmission (medicine), Zika Virus Infection, Reproduction, History, 19th Century, Bacterial Infections, Virus, nsp, Nonstructural proteins, Virus Diseases, HI, Herd immunity, Molecular Medicine, δCoV, Deltacoronavirus, Female, Infection, HGT, Horizontal gene transfer, Context (language use), CoVs, Coronaviruses, IL, Interleukins, Communicable Diseases, History, 21st Century, Article, WHO, World Health Organization, RTC, Replicase-transcriptase complex, ARDS, Acute respiratory distress syndrome, DMVs, Double-membrane vesicles, medicine, Humans, Mycoplasma Infections, RdRp, RNA-dependent RNA polymerase, TMPRSS2, Type II transmembrane serine protease, Molecular Biology, ERS, Endoplasmic reticulum, MHC, Major histocompatibility complex, ORF, Open reading frames, pp1a, Polyproteins 1a, ACE2, Angiotensin-converting enzyme 2 receptors, Bacteria, business.industry, SARS-CoV-2, Infant, Newborn, COVID-19, αCoV, Alphacoronavirus, Zika Virus, ZIKV, Zika Virus, History, 20th Century, biology.organism_classification, Virology, S, Spike, Infectious Disease Transmission, Vertical, NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells, Communicable disease transmission, ALA, Alpha-lipoic acid, Pregnant Women, Morbidity, business |
| الوصف: | Made available in DSpace on 2022-04-28T19:44:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-12-01 Agencia Nacional de Investigación e Innovación Comisión Sectorial de Investigación Científica Fondo Nacional de Desarrollo Científico y Tecnológico The molecular evolution of life on earth along with changing environmental, conditions has rendered mankind susceptible to endemic and pandemic emerging infectious diseases. The effects of certain systemic viral and bacterial infections on morbidity and mortality are considered as examples of recent emerging infections. Here we will focus on three examples of infections that are important in pregnancy and early childhood: SARS-CoV-2 virus, Zika virus, and Mycoplasma species. The basic structural characteristics of these infectious agents will be examined, along with their general pathogenic mechanisms. Coronavirus infections, such as caused by the SARS-CoV-2 virus, likely evolved from zoonotic bat viruses to infect humans and cause a pandemic that has been the biggest challenge for humanity since the Spanish Flu pandemic of the early 20th century. In contrast, Zika Virus infections represent an expanding infectious threat in the context of global climate change. The relationship of these infections to pregnancy, the vertical transmission and neurological sequels make these viruses highly relevant to the topics of this special issue. Finally, mycoplasmal infections have been present before mankind evolved, but they were rarely identified as human pathogens until recently, and they are now recognized as important coinfections that are able to modify the course and prognosis of various infectious diseases and other chronic illnesses. The infectious processes caused by these intracellular microorganisms are examined as well as some general aspects of their pathogeneses, clinical presentations, and diagnoses. We will finally consider examples of treatments that have been used to reduce morbidity and mortality of these infections and discuss briefly the current status of vaccines, in particular, against the SARS-CoV-2 virus. It is important to understand some of the basic features of these emerging infectious diseases and the pathogens involved in order to better appreciate the contributions of this special issue on how infectious diseases can affect human pregnancy, fetuses and neonates. Laboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la República Department of Infectious Diseases Faculty of Medicine Universidad de la República Cellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaeology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile Department of Physiology Faculty of Pharmacy Universidad de Sevilla Medical School (Faculty of Medicine) São Paulo State University (UNESP) University of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland Department of Pathology and Medical Biology University of Groningen University Medical Center Groningen (UMCG) Department of Molecular Pathology The Institute for Molecular Medicine Medical School (Faculty of Medicine) São Paulo State University (UNESP) Fondo Nacional de Desarrollo Científico y Tecnológico: 1190316 |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0925-4439 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74138c46cacbe2627e0f4293da6b884d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....74138c46cacbe2627e0f4293da6b884d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09254439 |
|---|