Mice immunization with Trypanosoma brucei gambiense translationally controlled tumor protein modulates immunoglobulin and cytokine production, as well as parasitaemia and mice survival after challenge with the parasite
| العنوان: | Mice immunization with Trypanosoma brucei gambiense translationally controlled tumor protein modulates immunoglobulin and cytokine production, as well as parasitaemia and mice survival after challenge with the parasite |
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| المؤلفون: | Eleonore Tour, Valérie Rodrigues, Anne Geiger, Géraldine Bossard |
| المساهمون: | Interactions hôtes-vecteurs-parasites-environnement dans les maladies tropicales négligées dues aux trypanosomatides (UMR INTERTRYP), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut de Recherche pour le Développement (IRD)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université de Bordeaux (UB), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA), University of Yaoundé [Cameroun], This work was supported by CIRAD and IRD (UMR INTERTRYP)., Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT) |
| المصدر: | Infection, Genetics and Evolution Infection, Genetics and Evolution, Elsevier, 2021, 87, pp.104636. ⟨10.1016/j.meegid.2020.104636⟩ Infection, Genetics and Evolution, 2021, 87, pp.104636. ⟨10.1016/j.meegid.2020.104636⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Trypanosoma brucei gambiense, [SDV]Life Sciences [q-bio], Gene Expression, L73 - Maladies des animaux, Mice, Trypanosomose, Trypanosoma brucei, Parasitaemia, biology, [SDV.BA]Life Sciences [q-bio]/Animal biology, immunisation, Tumor Protein, Translationally-Controlled 1, Variable surface glycoprotein, Host immunization, 3. Good health, Infectious Diseases, Cytokines, Tumor necrosis factor alpha, Antibody, L72 - Organismes nuisibles des animaux, Microbiology (medical), Relation hôte parasite, 030106 microbiology, Immunoglobulins, Microbiology, Antibodies, 03 medical and health sciences, Immune system, Translationally-controlled tumor protein, parasitic diseases, Genetics, medicine, Biomarkers, Tumor, Animals, Humans, Molecular Biology, Cytokine, Ecology, Evolution, Behavior and Systematics, Translationally controlled tumor protein (TCTP), Glycoprotéine, biology.organism_classification, medicine.disease, Disease Models, Animal, 030104 developmental biology, Trypanosomiasis, African, Immunization, Immunology, biology.protein, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Immunoglobuline, Trypanosomiasis |
| الوصف: | International audience; Fighting trypanosomiasis with an anti-trypanosome vaccine is ineffective, the parasite being protected by a Variable Surface Glycoprotein (VSG) whose structure is modified at each peak of parasitaemia, which allows it to escape the host's immune defenses. However, the host immunization against an essential factor for the survival of the parasite or the expression of its pathogenicity could achieve the same objective. Here we present the results of mouse immunization against the Translationally Controlled Tumor Protein (TCTP), a protein present in the Trypanosoma brucei gambiense (Tbg) secretome, the parasite responsible for human trypanosomiasis. Mice immunization was followed by infection with Tbg parasites. The production of IgG, IgG1 and IgG2a begun after the second TCTP injection and was dose-dependant, the maximum level of anti-TCTP antibodies remained stable up to 4 days post-infection and then decreased. Regarding cytokines (IL-2, 4, 6, 10, INFγ, TNFα), the most striking result was their total suppression after immunization with the highest TCTP dose. Compared to the control group, the immunized mice displayed a reduced first peak of parasitaemia, a 100% increase in the time to onset of the second peak, and an increased time of mice survival. The effect of immunization was only transient but demonstrated the likely important role that TCTP plays in host-parasite interactions and that some key parasite proteins could reduce infection impact. |
| وصف الملف: | text |
| اللغة: | English |
| تدمد: | 1567-1348 1567-7257 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7434566cfdd23da778193bb3f5b9702f http://agritrop.cirad.fr/598351/ |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....7434566cfdd23da778193bb3f5b9702f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15671348 15677257 |
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